iosr-JDMS   Volume-24 ~ Issue-6 ~ June 2025

Abstract: Résumé : Les métastases osseuses de la main et des pieds ou acrométastases sont extrêmement rares et apparaissent majoritairement dans le contexte de cancer pulmonaire. Leur présentation clinique, souvent trompeuse, peut simuler une pathologie inflammatoire, retardant ainsi le diagnostic étiologique. Nous rapportons le cas d’un patient présentant une tuméfaction douloureuse du pouce droit, chez qui le bilan d’imagerie et l’étude histologique ont révélé une acrométastase révélatrice d’un adénocarcinome bronchique. Cette observation souligne l’importance d’évoquer une origine néoplasique devant toute atteinte osseuse périphérique atypique, surtout en présence de facteurs de risque..........

[1] M.F. Amar Et Al. Tumeur Géante Du Pouce Révélant Un Adénocarcinome Pulmonaire ( A Propos D’un Cas). Chirurgie De La Main. 30(2011):133-135.
[2] M.-A. Lanfranchi Debra. Carcinome Pulmonaire Occulte A Cellules Squameuses Révélé Par Une Métastase Du Gros Orteil. Lettres A La Rédaction/Revue Du Rhumatisme 79(2012) 87-96
[3] A.Biyi Et Al. Acrométastase De La Main Et Du Pied Compliquant Un Cancer Mammaire. Chirurgie De Main 29(2010) 40-43
[4] P. Bigot Et Al. Acrométastase Révélée Par Une Douleur Isolée De La Main A Propos D’un Cas. Chirurgie De La Main 26 (2007) 300–302

Abstract: The incidence of triple-negative breast cancer (TNBC) is approximately 10-15% of all breast cancer cases around the world. It is important to search for novel therapeutic agents against TNBC since this form of cancer is a leading cause of death in women worldwide. Various genetic mutations in TNBC patients have been identified. EZH2 is an oncoprotein involved in breast, prostate, colon, and other cancers. In silico drug design and bioinformatics studies.....

Keywords : Triple Negative Breast Cancer, Drug Repurposing, Epithelial Mesenchymal Transition, Molecular Docking.

[1] Huang, Jinhua, Gou, Hongwei, Yao, Jia, Yi, Kaining, Jin, Zhigang, Matsuoka, Masao, & Zhao, Tiejun (2021). The Noncanonical Role Of EZH2 In Cancer. Cancer Science, 112(4), 1376-1382. Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/Cas.14840
[2] “Leading Causes Of Death.” Centers For Disease Control And Prevention, 6 February 2020,
Https://Www.Cdc.Gov/Nchs/Fastats/Leading-Causes-Of-Death.Html. Accessed 30 September 2020
[3] Noer, Julie B., Hørsdal, Oskar K., Xiang, Xi, Luo, Yonglun, Regenberg, Birgitte, "Extrachromosomal Circular DNA In Cancer: History, Current Knowledge, And Methods." Trends In Genetics (2022).
Https://Www.Sciencedirect.Com/Science/Article/Pii/S0168952522000348
[4] Patel, Shivali, Charles V. Preuss, And Fidelia Bernice. "Vancomycin." Statpearls [Internet]. Statpearls Publishing, 2022. Https://Www.Ncbi.Nlm.Nih.Gov/Books/NBK459263/
[5] Samaržija I, Tomljanović M, Novak Kujundžić R, Trošelj KG. EZH2 Inhibition And Cisplatin As A Combination Anticancer Therapy: An Overview Of Preclinical Studies. Cancers (Basel). 2022 Sep 29;14(19):4761. Doi: 10.3390/Cancers14194761 . PMID: 36230683; PMCID: PMC9561994..

Abstract: Objectives: To determine the frequency of different ENT diseases presenting at outpatient department and to educate people about different ENT diseases, their early treatment and prevention.
Methodology: An observational cross-sectional study was done in Prithvichandra hospital, Nawalparasi between from May 2024 to September 2024. A non-probability convenient sampling technique was used to collect data from 250 participants from patients presenting at OPD. Data about patient particulars and different diseases was collected through a well-structured questionnaire. Data was secured and confidentiality was maintained. Data was analyzed using SPSS 21........

Keywords: ENT diseases, OPD, frequency, otitis media, medical treatment

[1]. Medicinenet. Definition Of ENT.Available From URL: Http://Www.Medicinenet.Com/Script/Main/Art.Asp?Articlekey=3252
[2]. Seth Scott Bishop Diseases Of The Ear, Nose, And Throat And Their Accessory Cavities: A Condensed Text-Book. FA Davis Company, 1897.
[3]. Khan AR, Khan SA, Arif AU, Waheed R. Analysis Of ENT Diseases At Khyber Teaching Hospital, Peshawar. J Med Sci. 2013; 21(1): 7-9.
[4]. World Health Organization. Chronic Suppurative Otitis Media. Available From URL: Http: //Www. Who.Int/Pbd /Publications/ Chronic Suppurative Otitis_Media.Pdf.
[5]. Finnbogadottir AF, Petersen H, Laxdal T, Gudbrandsson F, Gudnason T, Haraldsson A Mastoiditis In Children In Iceland Laeknabladid. 2007; 93 (4): 275-80..

Abstract: The advantage of peritoneal dialysis (PD) is its continuous nature of fluid and solute removal, with continuous sodium removal causing reduced thirst and fluid intake, thus helping with balancing fluid status 1. The steady nature of this process likely preserves residual renal functions, which in turn has a bearing on mortality2. Although PD is known to work in anuric patients, it comes at a cost of larger dose (increased volumes, no dry time), which in turn exposes the peritoneal membrane to glucose related degradation, ultimately hastening its inability to sustain PD over prolonged periods and besides exposing it to the risk of encapsulating peritoneal fibrosis. This led to the.......

[1] Hideki Kawanishi Ans Misaki Moriishi. Clinical Effect Of Combined Therapy With Peritoneal Dialysis And Hemodialysis. Perit Dial Int; Vol 27:2007; Suppl2.
[2] Churchill Dn, Thorpe Ke, Nolph Kd Et Al. Increased Peritoneal Membrane Transport Is Associated With Decresased Patient And Technique Survival For Continuous Ambulatory Peritoneal Dialysis Patients. The Canada- Usa Peritoneal Dialysis Study Group. J Am, Soc Nephrol 1998;9,1281-92.
[3] Fukui H, Hara S, Hashimoto Y, Itzami N Et Al. Review Of Combination Of Peritoneal Dialysis And Hemodialysis As A Modality Of Treatment For End Stage Renal Disease. Ther Apher Dial 2004; 8:56-61.
[4] Aggarwal M, Clinard P, Burkart Jm. Combined Peritoneal Dialysis And Hemodialysis: Our Experience Compared Tp Others. Perit Dial Int 2003; 23:157-61
[5] Mcintyre Cw. Bi-Modal Dialysis: An Integrated Approach To Renal Replacement Therapy. Perit Dial Int 2004:24:547-53..

Abstract: This case report presents a 25-year-old immunocompetent patient with progressive dysphagia, ultimately diagnosed with mediastinal tuberculous lymphadenitis. Despite normal physical and laboratory findings, gastroscopy revealed multiple esophageal lesions, and imaging studies, including a thoracic CT scan and endoscopic ultrasound (EUS), identified two masses causing esophageal compression. Histopathological analysis and GeneXpert testing confirmed Mycobacterium tuberculosis infection.
This case underscores the importance of considering tuberculosis in the differential diagnosis of esophageal lesions, especially in endemic regions, and highlights the role of advanced imaging and biopsy in accurate diagnosis and timely treatment........

[1] Togun T, Kampmann B, Stoker NG, Lipman M. Anticipating The Impact Of The COVID-19 Pandemic On TB Patients And TB Control Programmes. Ann Clin Microbiol Antimicrob. 2020, 19:21. 10.1186/S12941-020-00363-1.
[2] Rivas-Garcia A, Sarria-Estrada S, Torrents- Odin C, Et Al. Imaging Findings Of Pott’s Disease. Eur Spine J 2013; 22: 567–578.
[3] Kim J, Jang Y, Kim KO, Et Al. Mediastinal Tuberculous Lymphadenitis Diagnosed By Endosonographic Fine Needle Aspiration. Korean J Gastroenterol. 2016, 68:312-6. 10.4166/Kjg.2016.68.6.312
[4] Koh WJ, Jeong YJ, Kwon OJ, Et Al. Chest Radiographic Findings In Primary Pulmonary Tuberculosis: Observations From High School Outbreaks. Korean J Radiol 2010; 11: 612–617.
[5] Pimenta AP, Preto JR, Gouveia AM, Et Al. Mediastinal Tuberculous Lymphadenitis Presenting As An Esophageal Intramural Tumor: A Very Rare But Important Cause For Dysphagia. World J Gastroenterol 2007; 13: 6104–6108.

Abstract: Background: To quantify the linear measurements of displacements occurring in mandibular teeth during enmasse distalization at various heights of buccal shelf screws and retraction hooks.
Materials and Methods. A finite element method was used for modeling mandibular teeth. The brackets, buccal tubes, retraction hooks and buccal shelf screws were designed by using 3D experience. In the mandibular model, buccal shelf screws were positioned at heights of 3 mm, 5 mm, and 8 mm below the cemento-enamel junction, and the retraction hooks at heights of.......

Key Word: Distalization, Buccal shelf screws, retraction hooks

[1] Almeida-Pedrin RR, Henriques JF, De Almeida RR, De Almeida MR, Mcnamara JA Jr. Effects Of The Pendulum Appliance, Cervical Headgear, And 2 Premolar Extractions Followed By Fixed Appliances In Patients With Class II Malocclusion. *Am J Orthod Dentofacial Orthop.* 2009 Dec;136(6):833-42.
[2] Janson G, Barros SE, De Freitas MR, Henriques JF, Pinzan A. Class II Treatment Efficiency In Maxillary Premolar Extraction And Nonextraction Protocols. *Am J Orthod Dentofacial Orthop.* 2007 Oct;132(4):490-8.
[3] Bussick TJ, Mcnamara JA Jr. Dentoalveolar And Skeletal Changes Associated With The Pendulum Appliance. *Am J Orthod Dentofacial Orthop.* 2000 Mar;117(3):333-43.
[4] Bolla E, Muratore F, Carano A, Bowman SJ. Evaluation Of Maxillary Molar Distalization With The Distal Jet: A Comparison With Other Contemporary Methods. *Angle Orthod.* 2002 Oct;72(5):481-94.
[5] Sreenivasagan S, Subramanian AK, Chae JM, Chadwick SM. Comparison Of Infrazygomatic Crest Mini-Implant And Inter-Radicular Mini-Implant As Skeletal Anchorage When Used For En Masse Anterior Retraction And En Masse Distalization: A FEM Study. *Int J Dent Oral Sci.* 2020 Dec 4;7(12):976-81..

Abstract: Introduction- Polycystic ovary syndrome (PCOS), also referred as hyperandrogenic an-ovulation (HA), or Stein Leventhal syndrome, is one of the most common endocrine disorders of reproductive age and was first described by Stein and Leventhal in 1935. They are at an increased risk of multiple morbidities including obesity, type II diabetes mellitus (DM-II), cardiovascular diseases (CVD), infertility, cancer, and psychological disorders........

Keywords: Polycystic ovarian syndrome, Non-alcoholic fatty liver disease, Fibroscan, Diabetes Mellitus, Waist circumference

[1] Doi SA, Al-Zaid M, Towers PA, Scott CJ, Al-Shoumer KA. Ovarian Steroids Modulate Neuroendocrine Dysfunction In Polycystic Ovary Syndrome. J Endocrinol Invest. 2005; 28:882-92.
[2] EL Hayek S, Bitar L, Hamdar HL, Mirza FG, Daoud G. Poly Cystic Ovarian Syndrome: An Updated Overview. Front Physiol. 2016; 7:124.
[3] Joshi B, Mukherjee S, Patil A, Purandare A, Chauhan S, Vaidya R. A Cross- Sectional Study Of Polycystic Ovarian Syndrome Among Adolescent And Young Girls In Mumbai, India. Indian J Endocrinol Metab. 2014;18(3):317-24.
[4] Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R. Prevalence Of Polycystic Ovarian Syndrome In Indian Adolescent. J Pediatr Adolesc Gynecol. 2011; 24:223- 7.
[5] The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus On Diagnostic Criteria And Long-Term Health Risk Related To Polycystic Ovary Syndrome. Fertil Steril. 2004;81(1):19-25.

Abstract: Congenital hypothyroidism (CH) is one of the major health problems and the main preventable cause of mental retardation in children. The incidence of congenital hypothyroidism varies across geographic areas and ethnicity. The exact incidence of congenital hypothyroidism in India is unknown. The incidence of CH has shown a wide variation across different states in India. A study done in Hyderabad showed an incidence of 1 in 1700 births.1 Studies by Desai et al based on a neonatal screening program in Mumbai places the incidence at 1: 2500 –1: 2800.8 Other studies done in Kerala and Kolkata and have shown a higher incidence of 1:500 to 1:600.20 CH if diagnosed promptly and.......

[1] Rama Devi AR, Naushad SM. Newborn Screening In India. Indian J Pediatr. 2004;71(2):157-60.
[2] American Academy Of Pediatrics AAP Section On Endocrinology And Committee On Genetics, And American Thyroid Association Committee On Public Health: Newborn Screening For Congenital Hypothyroidism: Recommended Guidelines. Pediatrics. 1993;91(6):1203-9.
[3] Dussault JH. The Anecdotal History Of Screening For Congenital Hypothyroidism. J Clin Endocrinol Metab. 1999 Dec;84(12):4332-4.
[4] Wu LL, Sazali BS, Adeeb N, Khalid BA. Congenital Hypothyroid Screening Using Cord Blood TSH. Singapore Med J. 1999 Jan;40(1):23-6.
[5] Ordookhani A, Mirmiran P, Najafi R, Hedayati M, Azizi F. Congenital Hypothyroidism In Iran. Indian J Pediatr. 2003 Aug;70(8):625-8...

Abstract: Background & Methods: Foregut duplication cysts are rare congenital malformations found in the esophagus, stomach, or duodenum. This prospective study reports four cases of foregut duplication cysts in children aged 2–4 years admitted to the pediatric surgery unit. Each underwent clinical evaluation, imaging, surgical excision, and histopathological analysis.......

Keywords: Foregut, duplication cyst, congenital, pediatric, esophageal, gastric, duodenal

[1] Keshri R, Prasad R, Chaubey D, Hasan Z, Kumar V, Thakur VK, Et Al Duplications Of The Alimentary Tract In Infants And Children Formos J Surg. 2021;54:39–44
[2] Sarin YK, Manchanda V, Sharma A, Singhal A. Triplication Of Colon With Diphallus And Complete Duplication Of Bladder And Urethra J Pediatr Surg. 2006;41:1924–6
[3] Rattan KN, Bansal S, Dhamija A. Gastrointestinal Duplication Presenting As Neonatal Intestinal Obstruction: An Experience Of 15 Years At Tertiary Care Centre J Neonatal Surg. 2017;6:5
[4] Ramakrishna HK. Intestinal Duplication Indian J Surg. 2008;70:270–3
[5] Sangüesa Nebot C, Llorens Salvador R, Carazo Palacios E, Picó Aliaga S, Ibañez Pradas V. Enteric Duplication Cysts In Children: Varied Presentations, Varied Imaging Findings Insights Imaging. 2018;9:1097–106.

Abstract: Prostate cancer is the most common cancer among African American’s. It is rarely diagnosed before the age of fifty years and when diagnosed earlier, it is often due to hereditary factors. The objective of this study was to review the role of adjuvant external beam radiotherapy in the Management of advanced prostate cancers. This study was a retrospective study spanning Five years from January 2015 to December 2019. About 144 Histopathologically.......

Keywords: Advanced prostate cancer, external beam radiotherapy, biochemical failure, castration resistance and Aba, Nigeria

[1] Benjamin W Fischer Valuck Etal Palliative Radiation Therapy For Prostate Cancer Patients With Bones Meta Stases At Diagnosis. A Hospital Based Analysis Of Patterns Of Care, RT Fractionation Selence And Overall Survival. Cancer Med 2018 August 17:7 (9) 4240-4250.
[2] Matthew J Boxer Etal Palliative Radiotherapy For Prostate Cancer Oncology (Williamston Park) 2014 April.
[3] Alysa Fairchild Etal Role Of Radiation Therapy And Radiopharmaceuticals In Bone Metastases Curr Opinion Support Palliat Care 2007 October
[4] Marte Gronlie Cameron, Christian Kersten, Ingvili Vistad, Rene Van Helvoirt, Kjetil Weyde, Christine Undseth, Ingvil Mjaaland, Eva Skovlund, Sophie D Fossa, Marianne Gronile Guren. Palliative Pelvic Radiotherapy For Symptomatic Incurable Prostate Cancer. A Prospective Multicenter Study. Radiotherapy And Oncology Volume 115, Issue 3 June 2015, Pages 314 To 320.
[5] R White, R Khor, M Bressec, G Duchesne, S Williams, D Bowden, K Tai, F Foroudi. Efficacy Of High Dose Palliative Radiotherapy For Localized Castration Prostate Cancer Clinical Oncology Vol. 27 Issue 1 January 2015, Pages 16-21

Abstract: Gross Hematuria, otherwise called Macroscopic Hematuria and visible Hematuria is a Urological symptom that brings alarm, anxiety and distress to the patient. Gross Hematuria can be caused by medical conditions but this study was undertaken to review the cases of Hematuria due to surgical causes in an adult population. It was a retrospective study spanning 5 years from January.......

Keywords: Gross Haematuria, causes, adult population and Aba.

[1] Vitalis Obisike Ofuru, Victor Abhulimen Surgical Haematuria: An Analysis Of Causes In A Southern Nigerian State Open Journal Of Urology Vol 12 N0.7 July 2022 .
[2] Ellen O. Connor, Aoife Mcvey, Stephanie Demkiw, Nathan Lawrentschuk, Declan G. Murphy. Assessment And Management Of Haematuria In The General Practice Setting. AJGP Vol 50 Issue 7 July 2021
[3] Newme, Kewith Nwangbo, Hajong Ranesy Dila, Bhuyan, Ratna Kanta. Clinical Study On Surgical Causes Of Haematuria. Journal Of Family Medicine And Primary Care. 10(1) P 265-271 Jan. 2021.
[4] O.O Mbonu, P.C Anene, A.M.E Nwofor. Gross Haematuria In A Negro Population: An Analysis Of 100 Adult Cases International Urology And Nephrology Vol 23, Pages 261-263, May 1991.
[5] Daben Dawam, G.D Kalayi, J.A Osuide I. Muhhamed. Haematuia In Africa: Is The Pattern Changing. BJU International April 2001 87(4) 326-330