Abstract: This comprehensive review delves into the burgeoning insights surrounding the gut microbiome's impact on drug metabolism and therapeutic efficacy, elucidating the potential implications for personalized medicine. As our understanding of the gut microbiome continues to unfold, it becomes increasingly apparent that individual variations in gut microbial communities play a pivotal role in shaping drug responses. Microbial enzymes interact with drugs, altering their metabolism and influencing bioavailability and pharmacokinetics. Furthermore, the intricate interplay between the gut microbiome and drug-metabolizing pathways can significantly influence treatment outcomes, including both drug efficacy and toxicity.....
[1]. Li, H., He, J., Jia, W. (2019). The Influence Of Gut Microbiota On Drug Metabolism And Toxicity. Expert Opinion On Drug Metabolism & Toxicology, 15(8), 843-855. Doi: 10.1080/17425255.2019.1633932
[2]. Suez, J., & Elinav, E. (2017). The Gut Microbiome And The Mechanisms Underlying Immune And Metabolic Diseases. The Journal Of Allergy And Clinical Immunology, 135(1), 3-13. Doi: 10.1016/J.Jaci.2014.11.012
[3]. Dong, Y., Wang, L., Burgener, S., & Guo, H. (2018). Gut Microbiota And Its Potential Application In Pharmacology. Frontiers In Pharmacology, 9, 224. Doi: 10.3389/Fphar.2018.00224
[4]. David, L. A., Maurice, C. F., Carmody, R. N., Et Al. (2014). Diet Rapidly And Reproducibly Alters The Human Gut Microbiome. Nature, 505(7484), 559-563.
[5]. Claesson, M. J., Jeffery, I. B., Conde, S., Et Al. (2012). Gut Microbiota Composition Correlates With Diet And Health In The Elderly. Nature, 488(7410), 178-184.