iosr-JPBS   Volume-17 ~ Issue-2 ~ Mar. - Apr. 2022

Abstract: The neogenic recombinases could be a source of genetic variety, and they could be involved in the pathways of genetic instability in carcinogenesis. The nuclear apoptosis-inducing factor 1 (NAIF1), which codes the protein NAIF1 that triggers apoptosis in several human malignancies, is one of these neogenic recombinases.
The purpose of this research is to look at the expression of the NAIF1 neogene in seven different glioma cell lines (H4, HS683, 42-MG-BA, A172, U87MG, U118MG, SK-N-MC).
The protein expression of the NAIF1 gene in samples of protein isolated from various glioma cell lines was investigated using the western blot method.......

Key words: DNA transposons, Domestication, Neogene, NAIF1, Glioma cell lines

Abstract: On March 11, 2020, the World Health Organization declared the outbreak of novel coronavirus (2019-nCoV) as a pandemic threat. It has become a global health hazard as a result of its widespread dispersion. Bangladesh is also experiencing the effects of the pandemic. The study's goal is to determine the CFR from the Bangladeshi population. The data was taken from the IEDCR's (Institute of Epidemiology Disease Control and Research) daily corona update in Bangladesh from July 1, 2020, to December 31, 2021. From July 2020 to December 2021, the total number of cases was 1440056, the total number of deaths was 26225, and the total number of recoveries was 1413831, resulting in a recovery rate of 98.2 percent and a CFR of 1.8 percent. It is promising that Bangladesh's CFR is fairly low when compared to developed-world countries..

Key words: CFR, IEDCR, RR, SARS-COV-2, COVID-19

Abstract: Background: Diabetes represents a real problem of public health. It is a disease with strong progression around the world. The present work aimed to document scientifically medicinal plants used as antidiabetic by Bwa traditional healers (BTH) in the Municipality I of Bamako, Mali. Material and Methods: A survey was conducted amongst the Bwa traditional healers using a semi-structured interview. The experimental investigation involved the plant material of five selected plants. The physicochemical analysis of samples was carried out using standard methods. The phytochemical screening was performed using colored and precipitated tube reactions associated to thin layer chromatography. The antiradical potential of polar extracts was determined using the scavenging reaction of the free-radical 1,1-Diphenyl-2-picryl-hydrazyl (DPPH+)........

Key words: Mali, Bô traditional medicine, phytochemistry, diabetes, antioxidant activity.

Abstract: Background: Sungkai (Peronema canescens) is one of the most popular medicinal plants used widely by Indonesian people during the COVID-19 Pandemic. This plant is commonly grown in tropical areas such as Indonesia, Thailand, and Malaysia. Empirically, P.canescens leaves are used by the community to treat fever, colds, malaria, intestinal worms, bruises, herbs for women after childbirth, and maintain a healthy body. Methods: This article summarizes the phytochemical compounds in P.canescens and their pharmacological activity based on the literature obtained from databases such as PubMed, ProQuest, ScienceDirect, and Google Scholar. The summarized articles were articles published in the last ten years. Results: Twenty-two papers containing the phytochemical and pharmacological activity of P.canescens were obtained.........

Key words: covid-19, immunostimulant, phytochemistry, pharmacology, sungkai.

Abstract: Background: Hypertension is globally considered to be the greatest mortality risk factor for both men and women and is regarded as a modifiable risk factor of the non-communicable diseases (NCDs) of lifestyle. The goal of the present study was to describe the antihypertensive medication prescribing patterns for inpatients with hypertension at a University teaching hospital in order to better understand the patterns of care for inpatients and Objectives: Primary objective: To evaluate the Prescribing Pattern in Hypertension. potential opportunities for improvement in hypertension management. Secondary objective: To find the Association of Hypertension with Type 2 DM. To Associate the Age with Hypertension.........

Key words: hypertensive, anti-hypertensive, HTN, Monotherapy; Prescribing Pattern

Abstract: Background: Garlic and turmeric are vital and beneficial spices used in the treatment of various illnesses. Pathogens' increasing multi-drug resistance drives researchers to look for new ways to treat infectious diseases. Therefore, garlic (Allium sativum) and turmeric (Curcuma longa) were tested for antibacterial properties. Materials and Methods: The agar well diffusion method was used to determine the Minimum Inhibitory Concentration (MIC) of garlic and turmeric extracts on S. aureus and E. coli.
Results: Results showed that both spices had inhibition on the organisms; however, garlic had a higher effect than turmeric. Both test organisms were inhibited by 100, 200, 300mg/ml of garlic and turmeric extracts. The control used was tetracycline which had the highest zone of inhibition. This showed that tetracycline is a strong antibiotic against the tested organisms Escherichia coli and Staphylococcus aureus.......

Key words: Antibacterial; Garlic; Turmeric; Staphylococcus aureus; Escherichia coli

Abstract: Why whales are stranding on beaches across the oceans, and kill themselves, is a question to which none of those who study their way of life could not give an answer. By converting solar energy into matter on earth, it increases the weight of our planet (geological layers,) and its gravity. This makes difficulties to bulky whales, and their maintain, and constantly swimming in the water. Fatigue, due to weakening hearts, and the increasing force of gravity, forces each of them to seek rest on the sandy beaches across the oceans. Stranded, rested, alone, whales are not possible to return to oceans. Because of it, from dinosaurs, survived only birds, creeper's reptiles, and crocodiles, taking rest on the solid ground. The Increasing gravity can cause many others of the species extinction, but it is not the subject of my interest. I give the word to biologists which have interest in this phenomenon..

Abstract: Purpose: The study was to determine the effects of various concentrations of Methyl acetate, butanol and N-hexane fractions of Terminalia catappa (Tropical Almond) red leaf extract on
adult Onchocerca volvulus, by modified in-vitro bioassay using the parameters of paralysis and death. This is an observation with fractions of ethyl acetate, n-hexane, and butanol, to
determine the polar constituents the more potent fraction........

Keywords: Terminalia catappa, Onchocerca volvulus, Methyl acetate, Butanol, N-hexane

Abstract: The driving motivation for the search of a new drug is a new disease or unmet clinical condition. Drug discovery is a expensive and difficult process which involves identifying drug responsive to a selective unestablished target. Solid State properties, X-ray Crystallography, Mixture Analysis and Spectrometry are used to monitor the modification of target after application of a new drug molecule and quality performance is measured. This leads to further optimization and selection of a molecule for the selected target. Post discovery, Regulations and Approvals through Drug Discovery a Pharmaceutical Development is achieved, here a review is done..

Keywords: Drug discovery, New drug molecule, Target validation, Compound screening, Pharmaceutical development.

Abstract: Background: The present research analysis of 10 AREB gene orthologous was carried out in order to determine their phylogeny, promoter region and the present of SSR motifs. ABA-responsive element binding protein (AREB) also called SlAREB was identified as gene responsible for mitigating the effects of some abiotic stresses such as water stresses (drought and flooding), cold and in some cases severe salt stress. Materials and Methods :The AREB gene orthologous DNA sequences were downloaded from National Centre for Biotechnology Information (NCBI) database. The phylogenetic analysis was done using MEGA 6 software. However, nucleotide frequency of the genes and Maximum Likelihood were also analysed using the same software.......

Keywords: AREB Gene, orthologues, phylogeny, promoter region, simple sequence repeats

Abstract: COVID-19 has affected millions of people around the world since its appearance in December 2019 and has caused a high number of deaths in its severe forms. Although there are no specific therapeutic agents for SARS-Cov2 infection, the anti-COVID-19 vaccine significantly reduces the morbidity and mortality associated with it.....