Series-1 (Jan-Feb 2019)Jan-Feb 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Hepatoprotective Activities of Girang Leaf Ethanol Extracts (Leea angulata Korth. Ex Miq) on Wistar Rats Induced by Paracetamol |
| Country | : | |
| Authors | : | Ni Luh Rustini || Ida Bagus Putra Manuaba || Bagus Komang satriyasa |
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: | 10.9790/3008-1401010105  |
Abstract: Paracetamol is an analgesic and antipyretic drug that has a toxic effect when it is used with excessive doses. The toxicity of paracetamol is caused by the formation of NAPQI reactive metabolites and paracetamol inducing the formation of free radicals which can cause liver cell damage. This study aims to test the hepatoprotective activity of ethanol extract of girang leaves (Leea angulata Korth. Ex Miq) in male white rats of the Wistar strain.Acute liver damage was done by inducing paracetamol at a dose of 750 mg / kg BW. Ethanol extract of girang leaves was given at a dose of 50, 100, 200, and 400 mg/kg per oral for 14 days. Liver biochemical parameters (ALT activity) of rat............
Key words: hepatoprotective effect, paracetamol, ethanol extract of girang leaves
[1]. Akhlaghi, M. and Bandy, B. 2009. Mechanisms of Flavonoid Protection Against Myocardial Ischemia-Reperfusion Injury. Journal of Moleculer and Cellular Cardiology. 46: 309-317
[2]. Akther, N., Shawl, A. S., Sultana, S., Chandan, B. K. 2013. Hepatoprotective Activity of Marrubium vulgare Against Paracetamol Induced Toxicity. Journal of Pharmacy Research 7 (7): 565-570
[3]. Akhter, S., Rahman, M. A., Aklima, J., Hasan, M. R., Chowdhurty, K. H. 2015. Antioxidative Role of Hatikana (Leea macrophylla Roxb) Partially Improve the Hepatic Damage Induced by CCl4 in Wistar Albino Rats. Biomed Res Int. 15 (1): 1-14
[4]. Alam, J., Mujahid, M., Badruddeen, Jahan, Y., Bagga, P., and Rahman, M. A. 2017. Hepatoprotective Potential of Ethanol Extract of Aquilaria agallocha Leaves Against Paracetamol Induced Hepatotoxicity in SD Rats. Journl of Traditional and Complementary Medicine. 7 (1): 9-13
[5]. Begum, M., Kumar, S., Balakris, S. 2015. Antioxidant and Hepatoprotective Activity of Andrographis paniculata Against Acetaminophen (Paracetamol) Induced H Rats. International Journal of Current Research. 3 (12): 864-868
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| Paper Type | : | Research Paper |
| Title | : | L-Ergothioneine Supplement Protect Testicular Functions In Cisplatin-Treated Wistar Rats. |
| Country | : | Nigeria |
| Authors | : | Ayobami DARE || Olugbemi Tope OLANIYAN || Maimuna Abdu SALIHU || Kehinde Linus ILLESANMI |
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: | 10.9790/3008-1401010613 |
Abstract: The present study was designed to investigate the role of L-ergothioneine supplement against cisplatin-induced reproductive toxicity in male wistar rats, regarding the antioxidant and cytoprotectant property of this supplement, and redox indices generated by cisplatin administration during administration.Twenty adult male wistar rats randomly divided into four groups (n=5) were used in this study and subjected to treatment as follows; Group I (control) received 10mL/kg distilled water for 14days; Group II (Cis alone) received a single dose........
Key words: L-ergothioneine, cisplatin, antioxidant, testis
[1]. Aksu, EH, Akman, O, Ozkaraca M, Omur AD, Ucar O (2015): Effect of Maclura pomifera extract against cisplatin-induced damage in reproductive system of male rats. Kafkas Universitesi Veteriner Fakultesi Dergisi. 21:397–403.
[2]. AldemirM,OkuluE,KösemehmetoğluK, Ener K, Topai F, Evigren O, Gurleyik E, Avci A (2014): Evaluation of the protective effect of quercetin against cisplatin‐induced renal and testis tissue damage and sperm parameters in rats. Andrologia. 46 (10), 1089-1097.
[3]. Amin AA, Hamza EA (2006): Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats. Asian Journal of Andrology. 8(5), 607–612.
[4]. Aruoma OI, Spencer JP, Mahmood N (1999): Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food and Chemical Toxicology. 37(11):1043-53. [5]. Askari A, Melville DB (1962): The reaction sequence in L-Ergo biosynthesis: hercynine as an intermediate. Journal of Biological Chemistry. 237:1615–8
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| Paper Type | : | Research Paper |
| Title | : | Role of Cinnamon Extract in the Protection against Amoxicillin/Clavulanate-Induced Liver Damage in Rats |
| Country | : | Egypt |
| Authors | : | Wafaa M. El-Kholy || Faried A. E. Hemieda || Ghada M. Elabani |
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: | 10.9790/3008-1401011421 |
Abstract: Amoxicillin/clavulanate (AC), which is effectively used in the treatment of several number of bacterial infections, may cause hepatotoxicity. Cinnamon extract contains natural products which showed antioxidant, anti-inflammatory and anti-bacterial properties. In the present study, two doses of AC, therapeutic (30 mg/kg) and double therapeutic (60 mg/kg), were orally given to rats alone or in combination with cinnamon (200 mg/kg) for 10 consecutive days, to test the potential protective impact of cinnamon extract against AC-induced hepatic injury. Obtained results showed significant increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST),.......
Key words: Amoxicillin/clavulanate, cinnamon, liver, oxidative stress, antioxidants
[1]. Finlay J, Miller L, Poupard J A. A review of the antimicrobial activity of clavulanate. J. Antimicrob. Chemother. 2003; 52: 18-21.
[2]. Labia R,Peduzzi J. Kinetics of beta-lactamase inhibition by clavulanic acid. Biochem Biophys Acta. 1978; 526: 572-579.
[3]. Larrey D, Vial T, Micaleff A , Babany G, Morichau-Beauchant M, Michel H, Benhamou J P. Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Gut. 1992; 33: 368-371.
[4]. Cars O, Molstad S N,Melander A. Variation in antibiotic use in the European Union. Lancet. 2001;357: 1851-1853.
[5]. Stricker B H, Van den Broek J W, Keuning J et al. Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin) Dig Dis Sci. 1989; 34: 1576–1580.
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| Paper Type | : | Research Paper |
| Title | : | Caesalpinia Crista Seed Exhibits Strong Anticoagulant and Antiplatelet Activity |
| Country | : | India |
| Authors | : | Chandramma Srinivasa || Sharath Kumar M Nandish || Jayanna Kengaiah || Chethana Ramachandraiah || Ashwini Shivaiah || Devaraja Sannaningaiah |
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: | 10.9790/3008-1401012230 |
Abstract: Caesalpinia Crista Seeds stores robust phytochemicals responsible for several therapeutic efficacy, hence it has been using from ancient time in the folk medicine. Although, researchers putting effort to validate its stored health benefits, its role in thrombosis was least explored. Thus, current study investigate the anticoagulant, antiplatelet and clot lysis efficiency of Caesalpinia Crista Seed Aqueous Extract (CCSAE). The protein blue prints of CCSAE revealed similar banding pattern from 15-200 kDa on 10 % SDS-PAGE suggests that CCSAE reserves only monomeric proteins. CCSAE exhibited proteolytic activity by degrading casein and gelatin with the specific activity of 0.160.......
Key words: CCSAE, protease, anticoagulant, antiplatelet, clot lysis.
[1]. Sanjeev Palta, Richa Saroa, and Anshu Palta. Overview of the coagulation system. Indian J Anaesth 2014;58(5): 515–523.
[2]. Anne-Celine Martin, Bernard Le Bonniec, Anne- Marie Fischer, Catherine Marchand-Leroux, Pascale Gaussem, Charles-Marc Samama, et al. Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis. International Journal of Cardiology 2013;168:4228-4233.
[3]. Norbert H. Hauel, Herbert Nar, Henning Priepke, Uwe Ries, Jean-Marie Stassen, Wolfgang Wienen, et al.Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors. J. Med. Chem 2002;45 (9):1757–1766.
[4]. M.Nandish SK, Kengaiah J, Ramachandraiah C, Shivaiah A, Chandramma, Girish KS, et al. Anticoagulant, antiplatelet and fibrin clot hydrolysing activities of flax seed buffer extract.Phcog Mag 2018;14:S175-83.
[5]. Sowmyashree G, Bhagyalakshmi M, Girish KS, Kemparaju K, Manohar Shinde, Devaraja S, et al. Anticoagulant and antiplatelet activities of jackfruit (artocarpus heterophyllus) seed extract. Int J Pharm Pharm Sci, Vol 7, Supple 1, 187-191..
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| Paper Type | : | Research Paper |
| Title | : | Diversity and habitat selection of aquatic beetles (Coleoptera). |
| Country | : | India |
| Authors | : | Shailendra Sharma || Gurudutt Sharma || Faisal Ahmad Pir |
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: | 10.9790/3008-1401013137 |
Abstract: In this study the diversity and habitat selection of aquatic Coleoptera has been assessed. The order Coleoptera includes more species than any order, constitutes 25 % of known life forms. Most of the species are terrestrial but some of them are aquatic however there is doubt whether a particular species is terrestrial or aquatic that is why Jach and Bhalke (2008) classify them as true water beetles, facultative water beetles,Phytophilous water beetles etc. depending upon the time they spend in or out of the water. More than 350000 species of beetles has been described so far out of which 12000 species are known from aquatic habitat. The order has been divided into 4 suborders.......
Key words: Aquatic, Beetles, Coleoptera, Diversity, Habitat
[1]. Angus, R.B., 1988. A New sibling species of Helophorus F. (Coleop- tera: Hydrophilidae), revealed by chromosome analysis and hybri- disation experiments. Aquatic Insects 10, 171-184
[2]. Arnett, Ross H. (2000). American Beetles: Archostemata, Myxophaga, Adephaga, Polyphaga: Staphyliniformia. CRC Press.1:8-10.
[3]. Balaram, P. (2005). Insect of tropical streams. Curr. Sci., 89: 914.
[4]. Balian, E.V.,C. Lévêque, H. Segers, K. Martens fresh water animal diversity assessment, Hydrobiologia 595 419- 442
[5]. Balke, M., I. Ribera & R. G. Beutel, 2005. The systematic position of Aspidytidae, the diversification of Dytiscoidea (Coleoptera, Adephaga) and the phylogenetic signal of third codon positions. Journal for zoological systematics and evolutionary research 43: 223–242.
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| Paper Type | : | Research Paper |
| Title | : | Bacterial and fungal profile in Chronic Suppurative Otitis Media in a tertiary care hospital in Uttarakhand |
| Country | : | India |
| Authors | : | J.Chauhan || S. Nautiyal |
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: | 10.9790/3008-1401013844 |
Abstract: Introduction: Chronic Suppurative Otitis Media (CSOM) is one of the most commonly encountered diseases in otorhinolaryngology practice. Material and methods: A total of 70 samples from 64 clinically diagnosed cases of CSOM were included in the study. The bacterial identification and antibiotic sensitivity of the isolates was carried out by automated method. Identification and antifungal susceptibility of yeast was performed using automated method. However identification of moulds was carried out by conventional methods. Result: Out of 70 samples 50% (35/70) showed positive bacterial culture. Among 64 patients, 53.12% (34/64) were males and 46.87% (30/64) were females.......
Key words: Antibiotics, CSOM, Bacterial infection, Antifungal agents, Fungal infection
[1] Shenoi P.M. Management of Chronic Suppurative Otitis Media. Scott Brown's text book of Otolaryngology.5th Edition, 1988; 5(3):215.
[2] Verhoeff M, van der Veen EL, Rovers MM, Sanders EM, & Schilder AGM. Chronic Suppurative Otitis Media: A Review. International Journal of Pediatric Otorhinolaryngology. 2006; 70 (1): 1–12.
[3] WHO. (2004). Chronic Suppurative Otitis Media Burden of Illness and management options. Report of WHO expert committee. Geneva: WHO, 2004.
[4] Harshika YK, Sangeetha S, & Prakash R. Original Research Article Microbiological profile of CSOM and their antibiotic sensitivity pattern in a tertiary care hospital. Int.J.Curr.Microbiol.App.Sci. 2015; 4(12): 735–43.
[5] Dayasena RP, Dayasiri MBKC, Jayasuriya C, & Perera DSC. Aetiological agents in Chronic Suppurative Otitis Media in Sri Lanka. Australasian Medical Journal. 2011; 4(2):101-4..
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| Paper Type | : | Research Paper |
| Title | : | Prescription Illegibility and Incompleteness Errors in Benghazi Ophthalmology Clinics: A Comparison of Handwritten and Computerized Prescriptions |
| Country | : | Libya |
| Authors | : | Huda Kutrani || Ainas Eltarhuni || Lamya S. El.Adouli || Abier A. Elshelmane |
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: | 10.9790/3008-1401014551 |
Abstract: Medication error is the second cause of patient safety incidents that could lead to morbidity and mortality. The incompleteness and illegibility of medication prescription are high in developing countries. Most developed countries adopted electronic prescribing that has led to a reduction of incompleteness and illegibility of medication prescription errors. This study aimed to compare the illegibility and incompleteness rate in handwritten and computerized prescriptions in two ophthalmology clinics in Benghazi. A cross-sectional descriptive study was performed in outpatient ophthalmology clinics. Data were collected from Al-Kish public ophthalmology polyclinic, and advanced ophthalmology private center. The handwritten and computerized prescriptions were assessed for incompleteness.......
Key words: incompleteness, illegibility, handwritten prescription, computerized prescription, Ophthalmology
[1]. Krishna J, Singh AK, Goel S, Singh A, Gupta A, Panesar S. A preliminary study on profile and pattern of medication errors from a tertiary care teaching hospital. IAIM 2015;2(7):93-8. Available from: http://iaimjournal.com/wwpontent/uploads/2015/ 07/iaim2015020715.pdf [accessed 2018 January 9].
[2]. Rijal A, Gautam K, Rijal AS. Errors on a handwritten Cardex: Is it time for a change. Nepal Med Coll J 2011;13(4): 267-71. Available from: https://www.ncbi.nlm .nih.gov/pubmed/23016477 [accessed 2018 March 9].
[3]. World Health Organization. Medication Errors: Technical Series on Safer Primary Care. Geneva: World Health Organization Press; 2016. Available from: http://apps. who.int/iris/bitstream/handle/10665/252274/9789241511643-eng.pdf?sequence=1 [accessed 2018 January 9].
[4]. Joshi A, Buch J, Kothari N, Shah N. Evaluation of Hand Written and Computerized Out-Patient Prescriptions in Urban Part of Central Gujarat. J Clin Diagn Res 2015;10: (6) 1-5. Available from https://www.ncbi.nlm.nih.gov/pmc /articles/PMC4963665/pdf/jcdr-10-FC01.pdf [accessed 2018 March 9].
[5]. Ansari M, Neupane D. Study on determination of errors in prescription writing: A semi-electronic perspective. Kathmandu Univ Med J 2009;7(3):238-41. Available from: https://www.nepjol.info/index.php/KUMJ/article/viewFile/2730/2422 [accessed 2018 January 9]..
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of In-vivo Curative and Haematopoietic Effect of Three Chinese Teas in Plasmodium bergheiInfectedMice |
| Country | : | Nigeria |
| Authors | : | Oderinde Abdulganiyu Olumuyiwa || Bankole Olukayode Olusola |
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: | 10.9790/3008-1401015261 |
Abstract: The emerging resistance of Plasmodium species to currently available antimalarial drugs remains a public health problem, hence the need for new effective, safe and affordable drugs. The curative and haematopoietic activities of 200 mg/kg and 400 mg/kg body weight of crude ethanolic extract of three commercial Chinese green teas (BIA 849, TD 570 and GB/T19598) were assessed utilizing Rane's curative antiplasmodial assay in mice infected with Plasmodium berghei (NK65 strain). The impact of the extracts on weight of the creatures were also determined. 200 mg/kg bwt of BIA 849 and GB/T19598 were as potent as 5 mg/kg bwt of chloroquine, with 100 % curative activities at 3 days post-treatment. TD570 at 200 mg/kg bwt was more powerful in stifling plasmodium, having 100 % curative activity at 4 days post treatment. 400 mg/kg body weight of TD570 and GB/T19598......
Key words: curative, haematopoietic, antiplasmodial, plasmodium berghei
[1]. Carter KH, Singh P, Mujica OJ, Escalada RP, Ade MP et al. Malaria in the Americas: trends from 1959 to 2011. American Journal Tropical Medical Hygiene 2015; 92: 302-316.
[2]. World Health Organization. Malaria in Africa. Roll Back Malaria Infosheet, 2015.
[3]. Lüthi B, and Schlagenhauf P. Risk factors associated with malaria deaths in travellers: a literature review. Travel Med Infect Diseases 2015; 13: 48-60.
[4]. Muregi FW, Ishih A, Miyase T, Suzuki T, Kino H, Amano T, Mkoji G.M, Terada M. Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice. J Ethnopharmacol. 2007; 111(1):190-5.
[5]. Ntie-Kang F, Onguéné PA, Scharfe M, Owono LCO, Megnassan E, Mbaze LM, Sippl W, Efange SMN. ConMedNP: a natural product library from Central African medicinal plants for drug discovery. RSC Adv. 2014; 4: 409-419..
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| Paper Type | : | Research Paper |
| Title | : | Anti –Mullerian Hormone is a new Marker for Ovarian function in females with polycystic ovary syndrome |
| Country | : | Iraq |
| Authors | : | Dr.Luma Alsarraj || Dr.Sajeda Al-Chalabi || Dr.Islam Al Jalili |
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: | 10.9790/3008-1401016265 |
Abstract: Anti-Mullerian Hormone (AMH) is a member of the transforming growth and differentiation factors in the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growth follicles to follicle stimulating hormone (FSH) 'The ovary-specific expression pattern in granulosa cells of growing non selected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. The aims of the present study were as follows: 1) to confirm the increase of serum AMH in patients with PCOS ; 2) to search for any relationship of serum AMH to the other hormonal features of PCOS; 3) whether metformin administration affects serum AMH levels.. Design: case series........
Key words: AMH, Female Infertility, PCOS.
[1]. Rajperts-demeyts E, Jorgensen N, Graem N, Muller J, Cate RL, and SK akkebaek NE. Expression of anti-mullerian hormone during normal and pathological gonadal development association with differentiation of Sertoli and granulose cells. J Clin Endocrinol and Metab 1999; 84:3836-3844.
[2]. Pellat L, Hanna L, Brincat M, Galea R, Brain H, Whitehead S, Mason H. Granulosa cell production of antimüllerian hormone is increased in polycystic ovaries. J Clin Endocrinol Metab2007; 92: 240–245.
[3]. Kevenaar ME, Meerasahib MF, Kramer P, Van de Lang-Born BM, de Jong FH, Groome NO, Themmen AP, and Visser JA. Serum anti-mullerian hormone levels reflect the size of the primordial follicle pool in mice. Endocrinol 2006; 147:3228-3234.
[4]. Piltonin T, Morin- Papunen L, Koivunen R, Perheentupa A, Ruokonen A,and Tapanainen JS.Serum antimullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Human Reprod 2005;20:1820-1826.
[5]. Durlinger ALL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JT, Grootegoed JA & Themmen APN .Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinol 2002;143: 1076–1084
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| Paper Type | : | Research Paper |
| Title | : | Protective role of Salvia officinalis against formalin induce nephrotoxicity in Swiss albino mice |
| Country | : | Libya |
| Authors | : | Ajlal A. Alzergy || Saad M.S. Elgharbawy || Ensaf. H. Abdalwahed |
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: | 10.9790/3008-1401016669 |
Abstract: Formalin is a constituent from many item of daily use including foods, Thus this study aimed to evaluate the histological changes induced by formalin on the kidney of adult male mice and evaluating the possible ameliorative role of salvia officinalis. Healthy male albino mice 8-10 weeks old weighting 24 - 30 gm were divided equally into four groups (n = 15 per group). The first group was given only the standard diet and served as the control, the second group was treated orally with aqueous extract of S. officinalis leaves (120 mg/kg bw.) for 3 successive weeks , the third group was administered with formalin (2.4 ml/kg body weight ) in drinking water for 3 successive weeks and the fourth group was Co-treated with formalin and S. officinalis. The specimens of kidney........
Key words: Salvia officinalis, Formalin, Histpathological kidney, Mice
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of antimalarial activity of a traditionally used medicinal plant in Ethiopia against Plasmodium berghei in Swiss Albino Mice |
| Country | : | Ethiopia |
| Authors | : | Sibhatu Gebrehiwot || Mirutse Giday || Berhanu Erko || Yalemtsehay Mekonnen |
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: | 10.9790/3008-1401017076 |
Abstract: The objective of the present study was to investigate the antimalarial activities of root extracts of Carissa spinarum Linn. The plant materials were collected from its natural habitat and extracted using 80% methanol and non-polar solvents. A rodent malaria parasite, Plasmodium berghei, which was maintained at the Aklilu Lemma Institute of Pathobiology laboratory, was inoculated into Swiss albino mice. The mice were infected with 1x107parasites intraperitoneally. The extracts were administered by standard intra gastric tube daily for four days starting from the day of parasite inoculation. The control groups were given the same amount of solvent (vehicle) used to suspend........
Key words: Malaria, Carissa spinarum, traditional medicine, Plasmodium berghei, in vivo
[1]. WHO.World malaria report, Geneva. World Health Organization. 2015.
[2]. WHO.World malaria report, Geneva. World Health Organization. 2014.
[3]. Woime AW.Changes in the spread of malaria in Ethiopia: case study from Awassa and Hossana area 2006– 2007. MSc Thesis; 2008. https:// brage.bibsys.no/xmlui/handle/11250/2438939. Accessed 25July 2018.
[4]. FMOH, National strategic plan for malaria prevention, control and elimination in Ethiopia: 2014–2020. Addis Ababa. Federal Ministry of Health of Ethiopia.2014.
[5]. Bekele, E.,Study on Actual Situation of Medicinal Plants in Ethiopia. Prepared for JAICAF. 2007 http://www.endashaw.com (Accessed on 28 August, 2018).
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| Paper Type | : | Research Paper |
| Title | : | Enhancement of solubility and dissolution rate of Leflunomide tablets by solid dispersion technique |
| Country | : | |
| Authors | : | T.Tirumala devi || Sk Faheem Ali || M.Manisha || P.Bhanu prasad || P.Jyothi |
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: | 10.9790/3008-1401017783 |
Abstract: Rheumatoid arthritis is an auto immune disorder that primarily affects joints. The disease causes sewere inflammation of joints,painful joints ;also causes Inflammation around lungs and heart. It increases the risk of heart strokes . The cause of disease is yet unclear predicted to be a combination of genetic and environmental factors. The disease is diagnosed by signs and symptoms and by laboratory tests .Around 41 /1,00,000 people are diagnosed with R.A. As per statistics about 24.5 million people are affected with R.A. About 38,000 deaths are reported in the year 2013. Leflunomide is a immuno suppresive disease modifying anti rheumatic drug that show its activity by inhibiting the mitochondrial enzyme ;Di hydro rotatateDehydrogenase........
Key words: Rheumatoid arthritis ,Leflunomide, Solid dispersion , solvent evaporation
[1]. TheFreeDictionary > oral administration of medication Citing: Mosby's Medical Dictionary, 8th edition. 2009
[2]. Sarode Ashish,Wang Peng,Cote Catherine,Worthen David R. Low-Viscosity hydroxypropylcellulose(HPC) grades SL and SSL:versatile pharmaceutical polymers for dissolution enhancement, controlled release, and pharmaceutical processing.AAPS Pharm Sci Tech.2013;14(1):151-159.
[3]. Dr.K.L.Senthilkumar and Y.sirisha. Enhancement of dissolution rate studies on solid dispersion of Aceclofenac. International Journal of Pharma and Bio Sciences. 2011; 2 (2):70-76.
[4]. P.Kumar, S.Kumar, A.kumar, M.Chander.Physicochemical Characterization of Solid Dispersion of Cefdinir with PVP K-30 and PEG 4000.International journal of pharmaceutical sciences and nanotechnology.2010; 3(2):948-956.
[5]. Tantishaiyaku V, Kaewnopparat N, Ingkatawornwong S. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone Int J Pharm.,1999;30(2):143-51.
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| Paper Type | : | Research Paper |
| Title | : | Beneficial Effects of Ethanolic Seed Extract of Cyperus esculentus on Blood Glucose and Sperm Quality in Alloxan-induced Diabetic Rats |
| Country | : | Nigeria |
| Authors | : | Njoku-Oji N.N || Ifegwu N.O || Umahi G.O || Sobanke A.O || Uchefuna R.C |
|
: | 10.9790/3008-1401018490 |
Abstract: Background: An important complication of diabetes mellitus is the disturbance in the male reproductive system. Aim: To determine the effects of ethanolic seed extract of C. esculentus on blood glucose and sperm quality in alloxan-induced diabetic rats. Materials and Methods: Twenty- five (25) normal adult male wistar rats weighing between 150-200g were used. Group I Served as the positive control group and received distilled water only. Groups II- V were the test groups and were induced with diabetes. Group II was the negative diabetic control group with no treatment. Group III received 400mg/kg of C. esculentus.......
Key words: Cyperus esculentus, Blood glucose, Diabetes, Sperm quality, Fertility
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