Volume-19 ~ Issue-6 ~ June 2026

Abstract: Background: Solvent use represents one of the major contributors to material consumption and waste generation in pharmaceutical manufacturing. Effective solvent management is therefore essential for improving both environmental sustainability and operational efficiency. Green chemistry metrics such as Process Mass Intensity (PMI), E-factor, and Solvent Intensity (SI) provide quantitative tools to evaluate process performance and identify waste hotspots. However, the integration of these metrics into plant-level managerial decision-making remains limited. This study.....

Keywords: Solvent management; Green chemistry metrics; Pharmaceutical manufacturing; Process Mass Intensity; E-factor

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Abstract: Benzimidazole derivatives are an important class of drugs because of their characteristic chemical and biological properties. They have been the centre of interest for medicinal chemists and pharmacologists. These derivatives are the basis of a vast array of drug compounds that can be used to fight a wide variety of diseases, from things like bacterial and fungal infections to long-term and complex diseases like cancer and high blood pressure. These are structurally versatile molecules with wide-ranging biochemical activity that makes them capable of interacting....

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