Volume-19 ~ Issue-1 ~ January 2026

Abstract: Background: Calcium (Ca²⁺) is an essential macroelement involved in critical physiological processes such as bone and teeth development, muscle contraction, blood coagulation, and nerve impulse transmission. A deficiency or excess of calcium in the human diet can result in various health issues, making accurate monitoring of......

Keywords: calcium, ion-selective electrode, potentiometry, mineral water, electrochemical analysis

[1]. Weaver, C.M., Et Al. (2016). Calcium In Human Health. Advances In Nutrition, 7(1), 1–6.
Https://Doi.Org/10.3945/An.115.009365
[2]. Zittermann, A., Et Al. (2020). Calcium Supplementation: Benefits And Risks. Nutrients, 12(10), 2980.
Https://Doi.Org/10.3390/Nu12102980
[3]. Montourcy, A., Chanliau, S., Et Al. (2021). Contribution Of Drinking Water To Calcium Intake In French Adults. Nutrients, 13(5), 1680. Https://Doi.Org/10.3390/Nu13051680
[4]. Snoeyink, V.L., & Wang, L. (2022). Water Chemistry (2nd Ed.). Wiley.
[5]. Sharma, S., Rawat, D.S., & Dwivedi, S.P. (2017). Determination Of Trace Metals In Drinking Water Using ICP-MS. Environmental Monitoring And Assessment, 189, 1–9. Https://Doi.Org/10.1007/S10661-017-5980-1.

Abstract: A new array of thienopyrimidine-based Schiff bases, specifically 2-(2-(substitutedbenzylidene) hydrazinyl)-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-one (4a–j), was prepared by a multistep convergent approach. Synthesis was initiated with a Gewald reaction involving ethyl methyl ketone, ethyl cyanoacetate, and elemental sulfur to afford ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate. Further cyclization with potassium thiocyanate gave the critical 2-mercaptothieno[2,3-d] pyrimidin4(3H)-one intermediate. The target Schiff bases were obtained by hydrazinolysis followed......

Keywords: Thieno [2,3-d] pyrimidine, Schiff bases, Gewald reaction, Heterocyclic synthesis, Drug discovery

[1]. El-Sayed, E. H.; Fadda, A. A. Synthesis And Cytotoxic Activity Of Some Novel Thieno[2,3-D:4,5-D′]Dipyrimidine Derivatives. Acta Chimica Slovenica 2018, 65, 853–864.
[2]. Tolba, M. S.; Sayed, M.; El-Dean, A. M. K.; Hassanien, R.; Abdel-Raheem, S. A. A.; Ahmed, M. Design, Synthesis And Antimicrobial Screening Of Some New Thienopyrimidines. Organic Communications 2021, 14(4), 365–376.
[3]. Lagardère, P.; Fersing, C.; Masurier, N.; Lisowski, V. Thienopyrimidine: A Promising Scaffold To Access Anti-Infective Agents. Pharmaceuticals 2022, 15(1), 35.
[4]. Chopra, N.; Kaur, K.; Kumar, S. Synthesis,
Molecular Docking And Antimicrobial Evaluation Of New Tetrahydrobenzothienopyrimidine Derivatives.
Journal Of Pharmaceutical And Chemical Sciences 2018, 2(6), 1–8.

Abstract: The medicinal relevance of Syzygium cumini (L.) Skeels as a widely used drug in traditional medicine due to its varied therapeutic benefit has been underutilized, but its anticancer and anti-inflammatory effects are under-studied. This paper has explored the pharmacological impact of Syzygium cumini aqueous seed extract on human carcinoma cell lines with further focus on cytotoxicity, induction of apoptosis and alteration of cytokines. The cells that were cultured and exposed to different concentrations of extract were the HeLa (cervical carcinoma), MCF-7 (breast......

Keywords: Syzygium cumini, carcinoma cell lines, apoptosis, cytotoxicity, anti-inflammatory activity, cytokine modulation

[1]. Abdulrahman, M. D., & Hama, H. A. (2023). Anticancer of genus Syzygium: a systematic review. Exploration of Targeted Anti-tumor Therapy, 4(2), 273.
[2]. Baldo, L. B. (2024). In vitro assessment of antitumor and antiparasitic effects of extracts and fractions from Persea Americana and Syzygium cumini.
[3]. Gaikwad, K. P., Chandak, C. S., Ambhore, J. P., Narkhede, M. B., & Ashwini, A. (2024). A review of the pharmacological and bioactive compounds of syzygium cumini. IP International Journal of Comprehensive and Advanced Pharmacology, 9(3), 166-176.
[4]. Kumar, S., & Singh, B. (2021). Syzygium cumini (jamun) its medicinal uses. Int. J. Pharmacogn, 8, 361-372

Abstract: Tuberculosis (TB) causes millions of deaths worldwide, and the emergence of MDR-, XDR-, and TDR-TB strains has reduced drug effectiveness. Though new drugs like pretomanid, bedaquiline, and linezolid show promise, their toxicity remains a concern. Hence, importance of innovative thiazole derivatives has gained increasing attention due to their diverse biological activities, structural versatility, and potential to act on new molecular targets within M. tuberculosis. Hence, in this paper we report a convenient and high-yielding solid-phase synthesis of novel......

Keywords: Organic Synthesis, 2,4-substituted thiazoles, 2-bromo-1-phenylethan-1-one, Anti-tuberculosis, Microplate Alamar Blue assay H37Rv strain

[1]. Fogel N. Tuberculosis: A Disease Without Boundaries. Tuberculosis. 2015, 95(5), 527–531.
Https://Doi.Org/10.1016/J.Tube.2015.05.017.
[2]. World Health Organization, Tuberculosis Fact Sheet; 2020. Https://Www.Who.Int/Ne Ws-Room/Fact-Sheets/Detail/Tuberculosis.
[3]. WHO Global Tuberculosis Report 2019; World Health Organization: Geneva, Switzerland, 2019.
[4]. Kumar V.; Patel S.; Jain R.; New Structural Classes Of Antituberculosis Agents. Med. Res. Rev. 2017, Doi: 10.1002/Med.21454