Abstract: SAHA or vorinostat is a new drug used in the management of cutaneous T-cell lymphoma when the disease persists, worsens or recurs during or after treatment with other drugs. It is an effective, well-tolerated treatment for this type of cancer. In addition to cutaneous T-cell lymphoma, the role of vorinostat in other types of cancer is being studied both as monotherapy and in combination therapy. While studies on the SAHA attachment and linker groups are well known, the role of the linker remains little studied today. Could the carbon number present in the linker improve the biological activity of SAHA? This is the question we set out to answer.
To this end, we......
[1]. O. Witt, H. E. Deubzer, T. Milde Et I. Oehme, «Hdac Family: What Are The Cancer Relevant Targets?,» Cancer Lett., Vol. 277, N° %11, Pp. 8-21, 2009.
[2]. M. Haberland, R. L. Montgomery Et E. N. Olson, «The Many Roles Of Histone Deacetylases In Development And Physiology: Implications For Disease And Therapy,» Nat. Rev. Genet., Vol. 10, N° %11, P. 32–42, 2009.
A. Grabarska Et J. Luszczki, «Histone Deacetylase Inhibitor Saha As Potential Targeted Therapy Agent For Larynx Cancer Cells,» J. Cancer, Vol. 8, N° %11, Pp. 19-28, 2017.
[3]. M. Arnold, D. Brown, O. Deeg, W. Errington, W. Haase, K. Herlihy, T. J. Kemp, H. Nimir Et R. Werner, «Hydroxamate-Bridged Dinuclear Nickel Complexes As Models For Urease Inhibition,» Inorg. Chem, Vol. 1669, N° %15, P. 2920–2925, 1998.
[4]. M. Tegoni, F. Dallavalle Et M. Amélia Santos, «Succinylhydroxamic Derivatives Of Alpha-Amino Acids As Mmp Inhibitors. Study Of Complex-Formation Equilibria With Cu2+, Ni2+ And Zn2+,» J. Inorg. Biochem., Vol. 98, N° %12, P. 209–218, 2004.
A. Mogal Et S. A. Abdulkadir, «Effects Of Histone Deacetylase Inhibitor ( Hdaci ); Trichostatin-A ( Tsa ) On The Expression Of Housekeeping Genes,» Mol. Cell. Probes, Vol. 20, P. 81–86, 2006.
[5]. F. Muri, M. Nieto, R. D. Sindelar Et J. S. Williamson, «Hydroxamic Acids As Pharmacological Agents,» Curr. Med. Chem., Vol. 9, N° %117, P. 1631–1653, 2002.