Abstract: Many indole derivatives are bioactive and several are useful clinically prescribed drugs, thus indole nucleus
has long been recognised as a good pharmacophore. The bioactive amine tryptamine and the amino acid
tryptophan contain indole nucleus. Not only natural but synthetic indole derivatives also show excellent
biological activities.As part of our interest in marine alkaloids and also on aminothiazoles, we observed that the
reported synthesis of dendrodoine will be useful only to prepare 3-N,N-dialkylamino derivatives alone, since
mono or unsubstituted ureas would react with Cl-CO-S-Cl differently, unlike disubstituted ureas. There exists no
direct cyclisation route to such acylthiadiazolylamines. Hence the preparation of dendrodoine analogs having
variety of substitients is deemed to be not easy. However the substitution of a 2-aminothiazole unit in place of
the amino-1,2,4-thiadiazole unit in dendrodoine appeared attractive.
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