Abstract: Fibrodysplasia Ossificans Progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive heterotopic ossification, wherein soft tissues are gradually replaced by bone. This paper examines the genetic and clinical features of FOP, focusing on the ACVR1 gene mutation and its disruption of the bone morphogenetic protein (BMP) signaling pathway. The study analyzes the progression of the condition, including hallmark symptoms such......
Key Word: Fibrodysplasia Ossificans Progressiva, ACVR1 mutation, heterotopic ossification, CRISPR therapy, rare genetic disease
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