iosr-JDMS   Volume-19 ~ Issue-5 ~ May 2020

Abstract: Objectives and Background:To describe clinical outcomes and prognosis i.e overall survival and relapse in the patients with paediatric B cell ALL (pBALL )with respect to minimal residual disease detection on day 15, day 29 and post consolidations in a tertiary care centre in eastern India. Minimal Residual disease (MRD) refers to the presence of disease in cases deemed to be in complete remission by conventional pathologic analysis. Prognostic importance of MRD in paediatric ALL is well accepted all over the world. This is the study where 8 colour flow cytometry (FCM) is used to detect MRD to assestreatment, diagnosis and prognosis of BcellALL. Method:Our Study had been running.....

KEY WORD: Paediatric ALL(pALL), MRD, Flowcytometry(FCM), Clinical Outcomes, Prognosis, overall survival

[1]. T Terwilliger, M abdul Hay. Acute lymphoblastic leukemia: a comprehensive review and 2017 Blood Cancer J. 2017 Jun; 7(6): e577.
[2]. Ampatzidou M et al. Prognosis significance of flowcytometry MRD long reduction during induction treatment of childhood ALL Leuk lymphoma 2019 Jan 60(1) 258-261
[3]. Conter et al Molecular response to treatment redefines all prognostic factors in children and adolescents with B‐cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP‐BFM ALL 2000 studyBlood/115,3206-3214
[4]. Marshal GM et al High‐risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation, Leukemia,27,1497-1503
[5]. Pieter R et al, Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: study ALL10 from the Dutch Childhood Oncology Group Journal of Clinical Oncology,34,2591-2601

Abstract: The advances in digital imaging systems combined with the availability to register CBCT data with digital models had made possible in fabrication of orthognathic surgery, CAD/CAM designed splints ,customized brackets ,and indirect bonding systems. Thusstereo lithography is used in wide range of dentistry, which helps in creating asymmetries ,fabricating, coating and land marking synthetic mandible. This article describes about stereo lithography and its application in various fields of dentistry.

[1]. Hourfar J, Kanavakis G, Goellner P, Ludwig B. Fully customized placement of orthodontic miniplates: a novel clinical technique. Head & face medicine. 2014 Dec 1;10(1):14.
[2]. Ercoli F, Tepedino M, Parziale V, Luzi C. A comparative study of two different clear aligner systems. Progress in orthodontics. 2014 Dec;15(1):1-5.
[3]. Russett S, Major P, Carey J, Toogood R, Boulanger P. An experimental method for stereolithic mandible fabrication and image preparation. The open biomedical engineering journal. 2007;1:4.
[4]. Guo, Q.Y., Zhang, S.J., Liu, H., Wang, C.L., Wei, F.L., Lv, T., Wang, N.N. and Liu, D.X., 2011. Three-dimensional evaluation of upper anterior alveolar bone dehiscence after incisor retraction and intrusion in adult patients with bimaxillary protrusion malocclusion. Journal of Zhejiang University SCIENCE B, 12(12), pp.990-997.
[5]. Kwon SY, Kim Y, Ahn HW, Kim KB, Chung KR. Computer-aided designing and manufacturing of lingual fixed orthodontic appliance using 2D/3D registration software and rapid prototyping. International journal of dentistry. 2014;2014..

Abstract: Introduction: All medical procedures involve some complications, even when they are performed by experts. The rate and severity of these complications depend on patient's state of health, age or general lifestyle. Even though the use of general anesthesia is considered safe, but it comes with certain complications. The risks of unexpected and potentially life threatening complications such as hypersensitivity or severe heart or lung problem can make the surgery difficult. Aim of the study:The aim of this study was to evaluate thecomplications of general anesthesia in different surgeries.

Keywords: General Anesthesia, Complications, Pain.

[1]. McCracken G, Houston P, Lefebvre G (2008) Guideline for the Management of Postoperative Nausea and Vomiting. J ObstetGynaecol Can 30: 600-607.
[2]. Gan TJ (2006) Risk Factors for Postoperative Nausea and Vomiting. AnesthAnalg 102: 1884-1898.
[3]. Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL (2010) Miller's Anaesthesia. (7thedn), Churchill Livingstone Elsevier, Philedelphia, 2: 2728-2755.
[4]. Gan TJ, Meyer T, Apfel CC, Chung F, Davis JP, et al. (2003) Consensus Guidelines for Managing Postoperative Nausea and Vomiting. AnesthAnalg 97: 62-71.
[5]. Harris, M. & Chung, F. 2013. Complications of General Anesthesia. Accessed on 13 October 2016. Retrieved from http://tinyurl.com/j48qmvd.

Abstract: Background: After myocardial infarction, inflammation is the important key factor involved in cardiac remodelling. Continuous activation of inflammatory markers like interleukins and tumour necrosis factors will leads to myocardial damage which ultimately results in heart failure. Very few studies have been done so far in relation to various inflammatory markers in relation to left ventricular function in cardiac patients. Aim: To determine serum levels of interleukin-1β, interleukin-2, interleukin-6, interleukin-8, interleukin-10 and tumour necrosis factor-α inrelation to left ventricular function in cardiac patients. Methods:We studied 229 cases of CVDs who were enrolled at Cardiology and Medicine at a tertiary care hospital, Mumbai. We further categorized above.......

Keywords: ELISA, cardiac diseases, LVEF, serum interleukins, serum TNF-α.

[1]. Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein, inflammation and coronary heart disease. Egypt Hear J. 2015;67:89–97.
[2]. Huffman MD, Prabhakaran D. Heart failure: epidemiology and prevention in India. Natl Med J India. 2010;23(5):283–8.
[3]. Dinarello CA, Simon A, M van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev | DRUG Discov. 2012;11:633–52.
[4]. Karpiński Ł, Płaksej R, Kosmala W, Witkowska M. Serum levels of interleukin-6, interleukin-10 and C-reactive protein in relation to left ventricular function in patients with myocardial infarction treated with primary angioplasty. Kardiol Pol. 2008;66(12).
[5]. Deokar SA, Dandekar SP, Shinde GA, Prabhu SS, Patawardhan M. Role of serum interleukin-6 in heart failure. Int J Adv Med. 2018;5(4):936–40.