iosr-JDMS   Volume-13 ~ Issue-7 ~ July-2014

Abstract: Aim: The aim of this studywas to measure the Vitamin-C levels in chronic kidney disease patients. Chronic renal failure is a clinical syndrome resulting in the progressive loss of renal function. The symptoms of chronic renal failure result not only from simple excretory failure but also from the onset of regulating failure, the kidney's failure to regulate certain substances, such as sodium & water. According to National Kidney Foundation- Kidney Dialysis Outcomes Quality Initiative (NKF-KDOQI) guidelines CRF is classified into 5 stages. An increased oxidative stress and inflammation are both common features of end stage renal disease.
Methods: Here, we determined the vitamin-C levels in patients with chronic kidney disease and the antioxidant status of vitamin-C in these patients.
Results: The mean plasma Vitamin – C concentration has found to be decreased in CKD patients when compared with the controls.
Conclusion: Vitamin C improves endothelial function in the resistance vasculature of patients with chronic renal failure, and this effect was abolished by an inhibitor of nitric oxide (NO) synthesis.There is insufficient evidence to recommend the use of vitamin C (ascorbate) in the management of patients with CKD.
Keywords: Oxidative stress, Antioxidant, Vitamin-C, Chronic renal failure (CRF).

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Abstract: Tuberculosis is an important cause of morbidity in the Indian society particularly among the low socioeconomic population and among the immunocompromised. Unlike pulmonary tuberculosis, extrapulmonary tuberculosis is less common and difficult to diagnose. We report a case series of primary extrapulmonary tuberculosis affecting rare sites of the body where tuberculosis is usually not demonstrated. Tuberculosis should be always considered as an important suspect in the etiology and differential diagnosis of any organic lesion.
Key Words: Extra pulmonary Tuberculosis, Rare Sites, Developing country

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Paper Type	:	Research Paper
Title	:	Systemic sclerosis presenting with severe digital ischemia. A rare case report
Country	:	India
Authors	:	Sourya Acharya , Samarth Shukla , Rasika Thakare , SN Mahajan
	:	10.9790/0853-13711113

Abstract: Digital ischemic loss is a cause of significant morbidity in patients with systemic sclerosis (SSc). Both the small and large digital arteries are involved causing perfusion defects leading to ischemia. Microvascular disease causes intimal proliferation and luminal narrowing of small digital arteries, macrovascular disease causes narrowing or occlusion of larger digital arteries. Immediate clinical evaluation and treatment are mandatory at the onset of critical digital ischemia to prevent digital loss. We present a case of 38 year old female suffering from systemic sclerosis who presented with acute onset severe digital ischemia of all four limbs.

Key words: systemic sclerosis, ischemia, micro vascular, macrovascular

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Abstract: An animal's ability to cope with the environmental changes depends on the integrity of cell communication and responses in terms of sensory perception and motor response1. Reaction time is an important parameter representing the integration of sensory, motor and coordination system of the body. It is the time interval between onset of stimulus and occurrence of response. This parameter is widely used in selection process of many occupations like pilots, car drivers and in industrial situation to prevent accidents.2,3Determination of reaction time has important implications in sports physiology also.4
In today's fast-paced world of digital technology, every person works invariably in complex setups, where he is required to react to a variety of situations or changes in the external environment promptly and correctly and so also the medical student. So, present study is carried out to see the reaction time in healthy young medical students and effect of caffeine on it.

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