Series-1 (Sep. – Oct. 2026) Sep. – Oct. 2026 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Artificial Intelligence-Driven Multi-Omics and Molecular Docking Approaches for Therapeutic Target Identification in Huntington’s Disease |
| Country | : | India |
| Authors | : | Vineeta Johri || Uma Kumari |
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: | 10.9790/ 264X-12050113  |
Abstract: Huntington's Disease (HD) is a rare, autosomal dominant neurodegenerative disorder marked by progressive motor problems, cognitive decline, and psychiatric symptoms, and the cause of this disease is an irregular expansion of CAG trinucleotide repeats, which are present in the huntingtin (HTT) gene. This gene encodes a mutant huntingtin protein, mHTT, with an extended polyglutamine segment. This defective and abnormal protein misfolds and aggregates, leading to neuronal dysfunction and selective neurodegeneration, primarily in the striatum and....
Keywords: Huntington’s disease, Artificial intelligence, multi-omics integration, Molecular docking, Neurodegeneration, biomarker discovery, machine learning, drug discovery, systems biology. Precision medicine
[1].
Barker, R. A., & Priller, J. (2013). Huntington’s Disease. Oxford University Press EBooks. https://doi.org/10.1093/med/9780199609536.003.0020
[2].
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., ... & Tabrizi, S. J. (2015). Huntington disease. Nature Reviews Disease Primers, 1, 15005. https://doi.org/10.1038/nrdp.2015.5
[3].
Peng, Q., Wu, B., Jiang, M., Jin, J., Hou, Z., Zheng, J., Zhang, J., & Duan, W. (2016). Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease. PLoS One, 11(2), e0148839.
[4].
Ross, C. A., & Tabrizi, S. J. (2019). Huntington’s disease: From molecular pathogenesis to clinical treatment. The Lancet Neurology, 18(1), 83–98. https://doi.org/10.1016/S1474-4422(18)30475-3
[5].
Tabrizi, S. J., Ghosh, R., & Leavitt, B. R. (2019). Huntingtin lowering strategies for disease modification in Huntington’s disease. Neuron, 101(5), 801–819. https://doi.org/10.1016/j.neuron.2019.01.039
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| Paper Type | : | Research Paper |
| Title | : | Artificial Intelligence-Driven Multi-Omics and Molecular Docking Approaches for Therapeutic Target Identification in Huntington’s Disease |
| Country | : | India |
| Authors | : | Vineeta Johri || Uma Kumari |
|
: | 10.9790/ 264X-12051426 |
Abstract: Huntington's Disease (HD) is a rare, autosomal dominant neurodegenerative disorder marked by progressive motor problems, cognitive decline, and psychiatric symptoms, and the cause of this disease is an irregular expansion of CAG trinucleotide repeats, which are present in the huntingtin (HTT) gene. This gene encodes a mutant huntingtin....
Keywords: Huntington’s disease, Artificial intelligence, multi-omics integration, Molecular docking, Neurodegeneration, biomarker discovery, machine learning, drug discovery, systems biology. Precision medicine
[1].
Barker, R. A., & Priller, J. (2013). Huntington’s Disease. Oxford University Press EBooks. https://doi.org/10.1093/med/9780199609536.003.0020
[2].
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., ... & Tabrizi, S. J. (2015). Huntington disease. Nature Reviews Disease Primers, 1, 15005. https://doi.org/10.1038/nrdp.2015.5
[3].
Peng, Q., Wu, B., Jiang, M., Jin, J., Hou, Z., Zheng, J., Zhang, J., & Duan, W. (2016). Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease. PLoS One, 11(2), e0148839.
[4].
Ross, C. A., & Tabrizi, S. J. (2019). Huntington’s disease: From molecular pathogenesis to clinical treatment. The Lancet Neurology, 18(1), 83–98. https://doi.org/10.1016/S1474-4422(18)30475-3
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| Paper Type | : | Research Paper |
| Title | : | Newborn Screening Methods in India: A Review of Policies, Rare Diseases, and Emerging Technologies |
| Country | : | India |
| Authors | : | Chitra Dabhul || Ashwini Teli || Pallavi Patil |
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: | 10.9790/ 264X-12052731 |
Abstract: Newborn screening (NBS) is a critical public health intervention enabling early detection of treatable congenital disorders before clinical symptoms manifest. India, with approximately 26 million annual births, has been slower than developed nations in implementing universal NBS. This review examines the current state of newborn screening in India, including the burden of rare genetic diseases, national policies (National Policy for Rare Diseases....
Keywords: Newborn screening, rare diseases, congenital hypothyroidism, tandem mass spectrometry, India, RBSK, ANMOL, UMMID
[1].
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Newborn Screening. Available at: https://www.nichd.nih.gov/health/topics/factsheets/newborn
[2].
Indian Pediatrics. Newborn Screening for Congenital Hypothyroidism in India: Let’s Just Do It! 2019;56:277-278.
[3].
Gupta T, Gupta T, Yadav D, Gupta M. The Need for Mandatory Newborn Screening in India: A Retrospective Analysis of 3-Year Data From a Multispecialty Private Hospital in Uttar Pradesh, India. Journal of Perinatology. 2024;24(1).
[4].
Department of Biotechnology, Government of India. UMMID Initiative. Available at: https://www.dbtindia.gov.in/scientific-directorates/information-systems-biology/ummid
[5].
Ministry of Health and Family Welfare, Government of India. National Policy for Rare Diseases 2021. Available at: https://main.mohfw.gov.in/sites/default/files/Final%20NPRD%2C%202021.pdf
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| Paper Type | : | Research Paper |
| Title | : | Comparative Evolutionary and Structural Analysis of Conserved Surface-Protein Regions in SARS-CoV, MERS-CoV, Influenza A and SARS-CoV-2 for Broad-Spectrum Antiviral Target Identification |
| Country | : | India |
| Authors | : | Roma Sharma || Dr. Surabhi Singh |
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: | 10.9790/ 264X-12053238 |
Abstract: Respiratory viruses like SARS-CoV, MERS-CoV, SARS-CoV-2, and influenza A are constantly evolving, which complicates the identification of conserved antiviral targets. In the present study, we combined sequence-based evolutionary and structural analyses of viral surface proteins to identify potentially conserved and functionally relevant regions. We carried out multiple sequence alignment and phylogenetic analysis of 13 representative viral sequences and....
Keywords: Respiratory viruses; SARS-CoV; MERS-CoV; SARS-CoV-2; Influenza A; Surface proteins; Evolutionary analysis; Phylogenetic analysis; Structural analysis; Antiviral broad spectrum.
[1].
Global, regional, and national burden of influenza-associated lower respiratory infections, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 | BMC Infectious Diseases | Springer Nature Link. https://link.springer.com/article/10.1186/s12879-025-12282-7 (accessed 2026-08-24).
[2].
Zheng, X.; Li, Y.; Ruan, D.; Lin, L.; Meng, R.; Zhao, D.; Yu, J.; Li, X.; Huang, H.; Zhou, M. Burden of Non-COVID-19 Lower Respiratory Infections and Etiologies in China and Globally: An Analysis for the Global Burden of Disease Study 2021. Chin. Med. J. Pulm. Crit. Care Med. 2025, 3 (3), 193–208. https://doi.org/10.1016/j.pccm.2025.08.006.
[3].
Sharma, R. Exploring the Binding Affinity Landscape of SARS-CoV-2 Variants: A Computational Approach. J. Med. Pharm. Allied Sci. 2024, 13 (3), 6566–6569. https://doi.org/10.55522/jmpas.V13I3.6555.
[4].
Oh, H.; Thi Thuy Tien, V.; Ahmed, S.; Choi, J.; Ryu, K.-J.; Yang, J. Host Glycan–Lectin Interplay in SARS-CoV-2 Infection. Int. J. Mol. Sci. 2026, 27 (3), 1608. https://doi.org/10.3390/ijms27031608.
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Frontiers | Viral glycoprotein-mediated entry and antibody-mediated immunity in HIV-1 and SARS-CoV-2 infection. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1733684/full (accessed 2026-08-27).