Series-1 (Mar. – Apr. 2026) Mar. – Apr. 2026 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Enhancing Clinical Trial Design With Decentralized, Patient-Centric Methods: Insights From A 2023 Product Discontinuation |
| Country | : | India |
| Authors | : | Bhanu Prakash Mettu |
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: | 10.9790/ 264X-1202010105  |
Abstract: Medical and product development greatly rely on the cornerstone of clinical trials. The outdated models, however, suffer from low patient reach, poor operating efficiency, and inadequate data quality. Efficiency and patient centrism are solutions to these barriers. In essence, the stop experience from 2023 should guide us towards more innovative thinking when it comes to trial design. In this article, I will concisely lay out some of the paradigm's established clinical trials' difficulty under the structure by discussing recruitment, data fragmentation, and retention rate issues......
Key Word: Clinical trial, medical product development, patient centric methods, decentralized clinical methods.
[1].
Craig Lipset, "Decentralized Clinical Trials: The Future Of Medical Research," Clinical Trials, Vol. 16, Pp. 1–6, 2019, January, Https://Doi.Org/10.1177/1740774518822552
[2].
Eric J. Topol, "The Patient Will See You Now: The Future Of Medicine Is In Your Hands," The Lancet, Vol. 385, Pp. 482–483, 2015, February, Https://Doi.Org/10.1016/S0140-6736(15)60102-5
[3].
Kenneth Getz, "Improving Patient Engagement In Clinical Trials," Applied Clinical Trials, Vol. 27, Pp. 18–24, 2018, March, Https://Www.Appliedclinicaltrialsonline.Com/View/Improving-Patient-Engagement-Clinical-Trials
[4].
Annick Anderson, "Remote Trials: Bridging The Gap Between Patients And Research," Journal Of Clinical Research Best Practices, Vol. 14, Pp. 1–7, 2018, June, Https://Www.Jclinicalresearch.Com/Remote-Trials-Bridging-Gap
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| Paper Type | : | Research Paper |
| Title | : | Prevalence And Molecular Charaterization Of Multiple Resistance Genes Associated With Escherichia Coli Isolated From Poultry Farms In Abakaliki Metropolis Ebonyi State |
| Country | : | |
| Authors | : | J. O Ikporo || A.C Nwuzo || O. E Udu-Ibiam || O. C Ote || M. I, Ogwa |
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: | 10.9790/ 264X-1202010611 |
Abstract: This study was conducted to determine the prevalence of multiple resistance genes associated with Escherichia coli from poultry farms in Abakaliki me-tropolis, Ebonyi State, Nigeria. A total of 500 poultry samples were collected from poultry samples as follows: cloacal n=125, feed n=125, water n=125 and meat n=125 and analyzed in the Microbiology Laboratory Complex of Ebonyi State University using microbiological standard. The E. coli isolates were identified by morphology, culture and biochemical tests and further subjected to antimicrobial....
Key Word: Antimicrobial resistance markers, poultry, bacterial resistance, Antibacterial susceptibility, Inhibition zones.
[1].
Aarestrup, F. M., Lertworapreecha, M., Evans, M. C., Bangtrakulnonth, A., Chalermchaikit, T., Hendriksen, R. S., Wegener, H. C (2013). Antimicrobial Susceptibility And Occurrence Of Resistance Genes Among Salmonella Enterica Serovar Weltevreden From Different Countries. Journal Of Antimicrobial. Chemotherapy, 23(52):715–718.
[2].
Abbassi-Ghozzi, I., Jaouani, A., Hammami, S., Martinez-Urtaza, J., Boudabous, A And Gtari, M (2015). Molecular Analysis And Antimicrobial Resistance Of Salmonella Isolates Recovered From Raw Meat Marketed In The Area Of Grand Tunisia. Pathology Biology, 10(8):13 -17.
[3].
Abd El-Aziz, N. K., Tartor, Y. H., Gharieb, R. M. A., Erfan, A. M., Khalifa, E., Said, M. A., Ammar, A. M And Samir, M (2021). Extensive Drug-Resistant Salmonella Enterica Isolated From Poultry And Humans: Prevalence And Molecular Determinants Behind The Co-Resistance To Ciprofloxacin And Tetracycline. Front Microbiology, 12: 738784.
[4].
Abdallah, H. M (2011). Extended-Spectrum Beta-Lactamases And/Or Carbapen Emases-Producing Enterobacteriaceae Isolated From Retail Chicken Meat In Zagazig, Egypt Epidemiology Of Infection, 14(4): 997–1005.
[5].
Brower, C. H., Mandal, S., Hayer, S., Sran, M., Zehra, A And Patel, S. J (2017). The Prevalence Of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant Escherichia Coli In Poultry Chickens And Variation According To Farming Practices In Punjab, India Environmental Health Perspect. 125: 077015.
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| Paper Type | : | Research Paper |
| Title | : | Statistical Analysis of Nundkol Lake Water |
| Country | : | India |
| Authors | : | Dr.Meenakshi Sharma || VinayKhandelwal |
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: | 10.9790/ 264X-1202010615 |
Abstract: This study investigates the physicochemical parameters influencing the ecological health of Nundkol Lake, located in the Kashmir region, with a focus on identifying contamination sources, particularly during high-activity seasons. Water samples were collected from surface and groundwater sources across different seasons to capture seasonal variations in water quality. The physicochemical parameters analyzed included temperature, pH, dissolved oxygen, and water transparency, which were measured to assess the quality of the water. Statistical analysis, specifically....
Key Word: Water Quality, Nundkol Lake, Microbial Contamination, Antibiotic Resistance, Environmental Conservation
[1].
Aftab, Begum, S. Y, Noorjahan, C. M., Dawood, Sharif, S, (2005), Physico-chemical and fungal analysis of a fertilizer factory effluent, Nature Environment & Pollution Technology, 4(4), 529-531.
[2].
Akshay R. Thorvat, N P Sonaje, M M Mujumdar “Development of regression model for the Panchaganga River water quality in Kolhapur city” Engineering Research and Applications, 1(4), 2011, pp1723-1730.
[3].
APHA. Standard methods for the examination of water & wastewater. Port city press, Baltimore, Maryland, USA. Ed. 2001.
[4].
ASTM International, (2003), Annual Book of ASTM Standards, Water and Environmental Technologyv. 11.01, West Conshohocken, Pennsylvania, pp 6-7.
[5].
B. Banakar, B. R. Kiran, E.T. Puttaiah, R.Purushotham& S. Manjappa (2005), "Hydrochemical Characteristics Of Surface Water In Chandravalli Pond, Near Chitradurga".
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| Paper Type | : | Research Paper |
| Title | : | Integrated Multi-Omics And Biopython Approaches For Target Identification Of Α-Synuclein Polymorph In Parkinson's Disease |
| Country | : | India |
| Authors | : | Dhanashri Mandra || Uma Kumari || Neha Singh || Aashritha Marouthu |
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: | 10.9790/ 264X-1202011221 |
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the degeneration of dopaminergic neurons and the abnormal aggregation of α-synuclein protein within neuronal cells. The misfolding of α-synuclein leads to the formation of amyloid fibrils and Lewy bodies, which are considered major pathological hallmarks of the disease. Structural polymorphs of α-synuclein fibrils have been identified, among which the cryo-EM resolved polymorph...
Key Word: α-Synuclein, Parkinson’s disease, Amyloid polymorph, Bio Python, Contact map, Protein aggregation, Therapeutic Targeting
[1].
Association Of Synuclein Alpha (SNCA) Gene Polymorphisms With Spontaneous Brain Activity In Patients With Parkinson’s Disease - Pubmed. Https://Pubmed.Ncbi.Nlm.Nih.Gov/39281177/ (Accessed 2026-02-12).
[2].
Bank, R. P. D. RCSB PDB - 8H04: Major Polymorph In Alpha-Synuclein Fibril Seeded By Cerebrospinal Fluid From A Postmortal Parkinson’s Disease Patient. Https://Www.Rcsb.Org/Structure/8H04 (Accessed 2026-02-12).
[3].
KUMARI, U.; Pacholee, K. In-Silico Drug Discovery-Based Approach To Treat Impairments In Patients Of Alzheimer’s Disease. In JETIR; 2023; Vol. 10.
[4].
Kumari, U.; Pradhan, M.; Mukherjee, S.; Chakrabarti, S. NGS ANALYSIS APPROACH FOR NEURODEGENERATIVE DISEASE WITH BIOPYTHON. In JETIR; 2023; Vol. 10.
[5].
Singh, N.; Kumari, U. Mult-Omics-Based Drug Discovery Pipelines Incorporating Machine Learning, AI, And Biopython In Parkinson’s Disease: A Case Study Of 5A Polymorph Of Alpha-Synuclein. 2026, 13 (2)..
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| Paper Type | : | Research Paper |
| Title | : | Fetal Bovine Serum In Cell Culture: Ethical Concerns & Emerging Non-Animal Alternatives |
| Country | : | India |
| Authors | : | Trupti Jain || Jancy Mary. E || Nikitha Chandar |
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: | 10.9790/ 264X-1202012230 |
Abstract: Fetal bovine serum, or FBS, is known for its rich composition of various factors, including growth factors, proteins, and essential nutrients. It is a supplement used in cell culture and universally applied in biomedical research, biopharmaceuticals and cultured meat production, etc. However, FBS is also intertwined with consequential concerns related to ethics, animal suffering, lack of openness in sourcing and batch-to-batch variability. These..
Key Word: fetal bovine serum, cell culture, ethical concerns, serum-free media, vegan alternatives
[1].
Amirvaresi, A., & Ovissipour, R. (2024a). Assessment Of Plant- And Microbial-Derived Protein Hydrolysates As Sustainable For Fetal Bovine Serum In Seafood Cell Culture Media. Future Foods, 10. Https://Doi.Org/10.1016/J.Fufo.2024.100443
[2].
Amirvaresi, A., & Ovissipour, R. (2024b). Evaluation Of Plant- And Microbial-Derived Protein Hydrolysates As Substitutes For Fetal Bovine Serum In Cultivated Seafood Cell Culture Media. Https://Doi.Org/10.1101/2024.03.27.587063
[3].
Anerillas, L. O., Wiberg, M., Kingham, P. J., & Kelk, P. (2023). Platelet Lysate For Expansion Or Osteogenic Differentiation Of Bone Marrow Mesenchymal Stem Cells For 3D Tissue Constructs. Regenerative Therapy, 24, 298–310.
Https://Doi.Org/10.1016/J.Reth.2023.07.011
[4].
Bianchetti, A., Chinello, C., Guindani, M., Braga, S., Neva, A., Verardi, R., Piovani, G., Pagani, L., Lisignoli, G., Magni, F., Russo, D., & Almici, C. (2021). A Blood Bank Standardized Production Of Human Platelet Lysate For Mesenchymal Stromal Cell Expansion: Proteomic Characterization And Biological Effects. Frontiers In Cell And Developmental Biology, 9.
Https://Doi.Org/10.3389/Fcell.2021.650490
[5].
Burnouf, T., Chou, M. L., Lundy, D. J., Chuang, E. Y., Tseng, C. L., & Goubran, H. (2023). Expanding Applications Of Allogeneic Platelets, Platelet Lysates, And Platelet Extracellular Vesicles In Cell Therapy, Regenerative Medicine, And Targeted Drug Delivery. In Journal Of Biomedical Science (Vol. 30, Issue 1). Biomed Central Ltd. Https://Doi.Org/10.1186/S12929-023-00972-W.
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| Paper Type | : | Research Paper |
| Title | : | Microbiological Study and Contaminant Analysis of Sambhar Lake, Jaipur (Rajasthan), for Evaluating Toxicity Risk to Birds, Aquatic Life, and Humans |
| Country | : | India |
| Authors | : | Prakriti Pareek || Manjul Mishra |
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: | 10.9790/ 264X-1202013135 |
Abstract: Sambhar Lake, located near Jaipur in Rajasthan, is India’s largest inland saline wetland and supports significant biodiversity as well as salt production activities. However, escalating anthropogenic pressures have resulted in extensive ecological degradation. This study presents an integrated assessment of microbiological and chemical contamination in Sambhar Lake to evaluate toxicity risks to birds, aquatic life, and humans. Seasonal water samples were collected from four representative sites and analyzed for physico-chemical parameters, heavy metals, and microbial indicators following standard protocols......
Key Word: Sambhar Lake, microbiological contamination, heavy metals, aquatic toxicity, avian risk, saline wetland.
[1].
A. H. Bhat and K. C. Sharma, “Physico-Chemical Analysis of Groundwater Quality of Adjoining Areas of Sambhar Lake, A Ramsar Wetland of Rajasthan, India,” Current World Environment, vol. 10, no. 3, pp. 1031–1038, 2015.
[2].
N. Chakravati, V. Gupta, R. K. Rahi, and D. K. Neelam, “Halophilic Bacterial Diversity of Sambhar Salt Lake, Rajasthan, India,” SVOA Microbiology, vol. 3, no. 2, pp. 23–29, 2022.
[3].
S. Pradhan et al., “A multi-temporal analysis for change assessment and estimation of algal bloom in Sambhar Lake, Rajasthan, India,” Environmental Monitoring and Assessment, vol. 188, no. 8, p. 465, 2016.
[4].
APHA, Standard Methods for the Examination of Water and Wastewater, 23rd ed. Washington, DC, USA: American Public Health Association, 2017.
[5].
USEPA, “Exposure Factors Handbook,” U.S. Environmental Protection Agency, Washington, DC, USA, 2011.
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| Paper Type | : | Research Paper |
| Title | : | NGS and Structure based Drug Designing of Natural Compound against Drug Resistant EGFR in Non-Small Cell Lung Cancer |
| Country | : | India |
| Authors | : | Riyaz Gurung || Uma Kumari |
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: | 10.9790/ 264X-1202013646 |
Abstract: Mutations in Epidermal Growth Factor Receptor drives disease progression and treatment resistance in Non-small Cell Lung Cancer. EGFR is a well-documented therapeutic target for management of NSCLC. Our research combines Next Generation Sequencing (NGS) and Structure Based Drug Design (SBDD) approaches to identify natural compounds as potential therapeutical. In our study, we targeted the triple mutated EGFR kinase domain (L858R T790M/C797S) using its crystal structure (PDB ID: 9D3W) to design EGFR tyrosine kinase inhibitors. NGS examined......
Key Word: Next-Generation Sequencing (NGS), Structure Based Drug Design (SBDD), Natural products, EGFR Mutants, Non-small Cell Lung Cancer (NSCLC), Molecular Docking, Targeted Therapy, Precision Medicine
[1].
Bajaj, T., & Kumari, U. (2025). Issue 3 www.jetir.org (ISSN-2349-5162). In JETIR2503614 Journal of Emerging Technologies and Innovative Research (Vol. 12). www.jetir.org
[2].
Bandbe, T., Saikia, J., & Kumari, U. (n.d.). NGS Analysis Human Papillomavirus Type 18 E2 DNA-Binding Domain Bound to its DNA Target with Biopython.
[3].
Bindod, H. V., Hatwar, P. R., Bakal, R. L., & Dafe, V. N. (2025). A Comprehensive Review of Cancer: Types, Pathophysiology, Diagnosis and Treatments. Journal of Drug Delivery and Therapeutics, 15(5), 114–122. https://doi.org/10.22270/jddt.v15i5.7104
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Ferro, A., Marinato, G. M., Mulargiu, C., Marino, M., Pasello, G., Guarneri, V., & Bonanno, L. (2024). The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic strategies. In Critical Reviews in Oncology/Haematology (Vol. 196). Elsevier Ireland Ltd. https://doi.org/10.1016/j.critrevonc.2024.104295
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Gillian Bethune, D. B., N. R., Z. X. (2010). Epidermal growth factor receptor (EGFR) in lung cancer an overview and..
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| Paper Type | : | Research Paper |
| Title | : | AI Based Multi-omics Analysis and structure-based drug discovery pipeline targeting KRas4A Mutations for Precision Oncology |
| Country | : | India |
| Authors | : | Sonali || Uma Kumari |
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: | 10.9790/ 264X-1202014756 |
Abstract: Overall analysis presents an integrated computational framework for precision oncology targeting KRAS4A mutations in Non-Small Cell Lung Cancer (NSCLC). The workflow combines Next-Generation Sequencing (NGS), Computer-Aided Drug Design (CADD), Artificial Intelligence (AI), and bioinformatics tools to systematically identify and evaluate potential therapeutic targets. Structural analysis of KRAS4A (PDB ID: 9GGY) revealed a stable conformation with a well-defined binding pocket between switch I and switch II regions. Sequence similarity.....
Key Word: KRAS4A; NSCLC; NGS; CADD; Artificial Intelligence; ML; Molecular Docking; Precision Oncology; Biopython
[1]. Corral de la Fuente E, Olmedo Garcia ME, Gomez Rueda A, Lage Y, Garrido P. Targeting KRAS in Non-Small Cell Lung Cancer. Front Oncol. 2022 Jan 10;11:792635. doi: 10.3389/fonc.2021.792635. PMID: 35083149; PMCID: PMC8784727.Mechanisms and current advances in treating KRAS-mutated lung cancer
[2]. Zhao, R., Shu, Y., Xu, W. et al. The efficacy of immunotherapy in non-small cell lung cancer with KRAS mutation: a systematic review and meta-analysis. Cancer Cell Int 24, 361 (2024). https://doi.org/10.1186/s12935-024-03498-9[3].
Ritu, K., Kumar, P., Singh, A. et al. Untangling the KRAS mutated lung cancer subsets and its therapeutic implications. Mol Biomed 2, 40 (2021). https://doi.org/10.1186/s43556-021-00061-0
[4]. Ghosh S, Bhuniya T, Dey A, Koley M, Roy P, Bera A, Gol D, Chowdhury A, Chowdhury R, Sen S. An Updated Review on KRAS Mutation in Lung Cancer (NSCLC) and Its Effects on Human Health. Appl Biochem Biotechnol. 2024 Jul;196(7):4661-4678. doi: 10.1007/s12010-023-04748-8. Epub 2023 Oct 28. PMID: 37897621