Series-2 (Nov. – Dec. 2025) Nov. – Dec. 2025 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Detection of multi drug resistant uropathogenic E coli through gene sequencing and assessment of cranberry based anti microbial potential: an emerging approach for UTI treatment. |
| Country | : | India |
| Authors | : | Pranab Kumar Das || Mayurakshi Basak || Debmalya Sarkar |
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: | 10.9790/ 264X-1106020110  |
Abstract: Urinary Tract Infections (UTIs) are infections that can impact any section of the urinary tract- the kidneys, bladder, ureters and urethra. They are among the most prevalent bacterial diseases, with over fifty percent of women experiencing at least one episode in their lifetime. Although urinary tract infections are usually managed....
Key Word: Urinary tract infections, plant extract, cranberry, antibiotic resistance, Vaccinium macrocarpon, gene sequencing, non-drug UTI prevention, alternative treatment, antimicrobial efficacy
[1].
Morand, A., Cornu, F., Dufour, J.C., Tsimaratos, M., Lagier, J.C., Raoult, D., 2019. Human bacterial repertoire of the urinary tract: a potential paradigm shift. J. Clin. Microbiol. 57(3). doi: 10.1128/JCM.00675-18.
[2].
Williams, G., Stothart, C.I., Hahn, D., Stephens, J.H., Craig, J.C., Hodson, E.M., 2023. Cranberries for preventing urinary tract infections. Cochrane Database Syst. Rev. 2023(11):CD001321. doi: 10.1002/14651858.CD001321.pub7.
[3].
Sihra, N., Goodman, A., Zakri, R., Sahai, A., Malde, S., 2018. Nonantibiotic prevention and management of recurrent urinary tract infection. Nat. Rev. Urol. 15(9):1-8. doi: 10.1038/s41585-018-0106-x.[4].
Qiao, L.D., Chen, S., Yang, Y., 2013. Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study. BMJ Open 3(12):e004152. doi: 10.1136/bmjopen-2013-004152.
[5].
Schappert, S.M., Rechtsteiner, E.A., 2011. Ambulatory medical care utilization estimates for 2007. Vital Health Stat. 13:1-38.
[6].
Simmering, J.E., Tang, F., Cavanaugh, J.E., Polgreen, L.A., Polgreen, P.M., 2017. The increase in hospitalizations for urinary tract
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical Screening and Molecular Target Binding Ability of some boi-active constituents of Costus afer |
| Country | : | Nigeria |
| Authors | : | Omekara, Amaka Maduabuchi || Akubugwo Emmanuel Iroha || Chibuzo Henry Onwuegbuchulam || Kelechi Uzoma Akataobi || Eke Ugorji Iheanacho |
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: | 10.9790/ 264X-1106021139 |
Abstract: Costus afer is used in ethnomedicine to treat and manage a wide range of diseased conditions. Thirty compounds were identified in the GC/MS analysis of Costus afer stem juice. Among the compound identified are; 2 Furancaboxaldehyde, 5-(hydroxymethyl)- was present in 70.357% forming one of the major constituents in the juice and Dihydro-3-methylene-5-methyl-2-furanone (0.149%) having the least quantity. Gas Chromatography-Mass Spectophotometry analysis of Costus afer aqueous leaves extract revealed the presence of seventy-seven bio-active.......
Keywords: Phyto-constituents, Molecular Docking, Costus afer, Anti-inflammatory, Gas Chromatography-mass spectrometry.
[1].
Tailulu A, Cui H, Wu L, Shen Y, Shi P. Study on bioactivities of Morinda citrifolia L. fruit hydroalcoholic extracts and detection of novel phytoconstituents by UPLC-Q-exactive orbitrap-tandem mass spectrum analysis. Explor Drug Sci. 2025;3:1008121. and
[2].
Noureddine Chaachouay and Lahcen Zidane 2024, Plant-Derived Natural Products: A Source for Drug Discovery and Development. Drugs Drug Candidates 3(1), 184-207
[3].
Mohamed T. El-Saadony, Ahmed M. Saad, Dina Mostafa Mohammed, Sameh A. Korma, Mohammad Y. Alshahrani, Ahmed Ezzat Ahmed, Essam H. Ibrahim, Heba M. Salem, Samar Sami Alkafaas, Abdullah M. Saif, Sara Samy Elkafas, Mohamed A. Fahmy, Taia A. Abd El-Mageed, Mariam M. Abady, Hanya Y. Assal, Marawan K. El-Tarabily, Betty T. Mathew, Synan F. AbuQamar, Khaled A. El-Tarabily, Salam A. Ibrahim , (2025). Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review, Frontiers in Immunology 16:1491777
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| Paper Type | : | Research Paper |
| Title | : | How Should India Tackle Diabetes - A Silent Syndrome Load? |
| Country | : | India |
| Authors | : | Zamiruddin Ansari |
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: | 10.9790/ 264X-1106024044 |
Abstract: Diabetes mellitus type 2 or (T2DM) or Non-Insulin Depended Diabetes Mellitus (NIDDM) is the most common endocrine disorder whose incidence has been continuously growing around the world with the number of individual’s affected anticipated to double in the next decade as the world’s population ages. As a result of this tendency, it is quickly becoming a syndrome in some parts of the world, with the number of individuals affected anticipated to double in the next decade as the world’s population ages, adding to the already existing load on healthcare....
Key Words: Diabetes, Syndrome, Complications, Factors, Diagnosis, Guidelines, Drug therapy
[1].
Patel P, Patel H, Bhagiya H, Kacha B, Christian A. 2022. Type-2 Diabetes Mellitus: A Review of Current Trends. J.Pharm.Res; 21(4): 95-104
[2].
Ansari Z, Kumar VB, Padmadeo SR and Mohan A. 2020 Anti diabetic potential of a novel hypoglycemic active principle from Bittergourd (Momordica charantia) seeds in alloxan-induced diabetic rats. Biospectra, Vol-15(2), pp. 123-126[3].
Ansari Z and Ahmad S. 2025 Antidiabetic Potential of an Insulin-Like Molecule from the Seeds of Momordica charantia Linn. In Experimental Diabetes. IOSR Journal Of Pharmacy and Biological Sciences (IOSR-JPBS). Volume 20, Issue 5 Ser. 1 (Sept. – Oct. ), pp. 37-40.
[4].
NCD Risk Factor Collaboration (NCD-RisC) 2024. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a polled analysis of 1108 population - representative studies with 141 million participants ,Lancet 404 – 2077 – 2093.
[5].
Anjana RM etal; 2023: Metabolic non- communicable disease health report of India. The ICMR- INDIAB India national Cross-sectional Study (ICMR-INDIAB- 17). Lancet, Volume II, July, Issue 7, P477-489
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| Paper Type | : | Research Paper |
| Title | : | Computational Analysis of PD-L1 Structural Variants and Expression Profiles Using Next-Generation Sequencing for Predicting Immunotherapy Response in Non-Small Cell Lung Cancer (NSCLC) |
| Country | : | India |
| Authors | : | Uma Kumari || Dhanashri Mandra || Sonali |
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: | 10.9790/ 264X-1106024552 |
Abstract: Non-small cell lung cancer (NSCLC) represents the majority of lung cancer cases and remains a major contributor to global cancer mortality. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway have transformed NSCLC therapy, yet a significant proportion of patients exhibit poor or no response. This study integrates next-generation sequencing (NGS)-derived genetic alterations with structural bioinformatics analysis of PD-L1 (PDB ID: 8ALX) to evaluate molecular determinants influencing immunotherapy outcomes. Computational.......
Keywords: PD-L1, NSCLC, Immunotherapy, Structural Variants, NGS, Protein Modelling, Ig-like Domains, Bioinformatics pipeline
[1].
Aran, D., Sirota, M., & Butte, A. J. (2015). Systematic pan-cancer analysis of tumor purity. Nature Communications, 6, 8971. https://doi.org/10.1038/ncomms9971
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Cristescu, R., Mogg, R., Ayers, M., Albright, A., Murphy, E., Yearley, J., Sher, X., Liu, X. Q., Lu, H., Nebozhyn, M., et al. (2018). Pan-tumor genomic biomarkers for PD-1 checkpoint 3.blockade–based immunotherapy. Science, 362(6411), eaar3593. https://doi.org/10.1126/science.aar3593
[3].
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., et al. (2015). Pembrolizumab for the treatment of non–small-cell lung cancer. New England Journal of Medicine, 372(21), 2018–2028. https://doi.org/10.1056/NEJMoa1501824
[4].
Herbst, R. S., Morgensztern, D., & Boshoff, C. (2018). The biology and management of non-small cell lung cancer. Nature, 553(7689), 446–454. https://doi.org/10.1038/nature25183
[5].
Kataoka, K., Shiraishi, Y., Takeda, Y., Sakata, S., Matsumoto, M., Nagano, S., Maeda, T., et al. (2016). Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers. Nature, 534(7607), 402–406. https://doi.org/10.1038/nature18294
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| Paper Type | : | Research Paper |
| Title | : | Haematological Parameters of Alloxan-Induced Diabetic Rats Treated with Ethanol Extract of Talinum Triangulare |
| Country | : | |
| Authors | : | Useh, M. P. A, Bobson || P. M, Udo, E. S || Afangide, E. J. |
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: | 10.9790/ 264X-1106025358 |
Abstract: Thirty albino rats were divided into six groups. Groups 1, 2, 3, 4 and 5 were induced diabetes using Alloxan. Groups 1, 2 and 3 were treated with 200mg/kg, 400mg/kg, and 600mg/kg body weights of the plant extract respectively. Group 4 (positive control) was treated with the antidiabetic drug Metformin. Group 5 (negative control) was untreated, Group 6 was the normal control. All rats were fed with rat feed and distilled water ad libitum for 28 days and were then sacrificed for blood collection and analysis. Results revealed a significant decrease in HB.....
Key words: Talinum triangulare, Alloxan-induced diabetes, Hematological parameters, Lipid profile
[1].
Afolabi, O. B..& Oloyede, O. I. (2014). Antioxidant Properties of the Extracts of Talinum triangulare and its Effect on Antioxidant Enzymes in Tissue Homogenate of Swiss Albino Rat. Toxicology International. 21(3):307.
[2].
Agu, K. (2018). Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management. Journal of Insulin Resistance. 3 (1): 1-10. [ Google Scholar]
[3].
Agunbiade, S. O., Ojeziele, S. O., Alao, O.O. (2015). Evaluation of the Nutritional, Phytochemical Compositions and Likely Medicinal Benefits of Veronica amygdalina, Talinum triangulare and Ocimum basilicum Leafy Vegetables. Advances in Biological Research 9(3): 151-155.
[4].
Aja, P. M. Okaka, A. N. C. Onu, P. N. Ibiam, U. Urako, A. J. (2010). Phytochemical Composition of Talinum triangulare (Water leaf) Leaves. Pakistan Journal of Nutrition 9(6): 527-530.
[5].
Arkew, M. M., Yamane, T., Mengistu, Y., Gemechu, K., and Tesfaye, G. (2012). Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study. PLoS One 16: e0253286. Doi: 10: 1371/journal.pone.0253286.
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| Paper Type | : | Research Paper |
| Title | : | Interpreting the function of VapBC Toxin–Antitoxin Family of Mycobacterium tuberculosis through in Silico Approaches in an E. coli System |
| Country | : | India |
| Authors | : | Neetu Yadav || Sahabjada || Pankaj Gupta || Roshini Singh || Sanjay Mishra |
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: | 10.9790/ 264X-1106025968 |
Abstract: Mycobacterium tuberculosis (Mtb) harbors a great number of Toxin-Antitoxin (TA) systems, in which half of them belong to virulence linked proteins B and C (VapBC) family that has a typical PilT N-terminus domain and ribonuclease activity. Functional perceptions into Mtb VapBC TA modules untangled their function in adaptation to numerous host-mediated stressors, including oxidative/nitrosative, chemical and nutrient starvation concomitant....
Key words: Mycobacterium tuberculosis; toxin-antitoxin system; VapBC family; VapC toxin
[1]. Aakre, C.D., Phung, T.N., Huang, D. & Laub, M.T. (2013). A Bacterial Toxin Inhibits DNA Replication Elongation through A Direct Interaction with the Beta Sliding Clamp. Mol Cell 52, 617–628.
[2].
Allué-Guardia, A., García, J. I., & Torrelles, J. B. (2021). Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment. Frontiers in Microbiology, 12, 612675.
[3]. Bahl, A., Rajagopalan, M., Rakshit, R., Kant, S., Pandey, S., & Tripathi, D. (2025). Toxin–Antitoxin Modules: Genetic Elements with Many Faces and Functions. Bacteria, 4(4), 61.
[4].
Blum, M., Andreeva, A., Florentino, L. C., Chuguransky, S. R., Grego, T., Hobbs, E., Pinto, B. L., Orr, A., Paysan-Lafosse, T., Ponamareva, I., Salazar, G. A., Bordin, N., Bork, P., Bridge, A., Colwell, L., Gough, J., Haft, D. H., Letunic, I., Llinares-López, F., Bateman, A. (2024). InterPro: The Protein Sequence Classification Resource in 2025. Nucleic Acids Research, 53(D1), D444–D456.
[5]. Damiano, D. K., Azevedo, B. O. P., Fernandes, G. S. C., Teixeira, A. F., Gonçalves, V. M., Nascimento, A. L. T. O., & Lopes, A. P. Y. (2024). The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability. Microorganisms, 12(8), 1660
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| Paper Type | : | Research Paper |
| Title | : | Effects of co-administration of Naja melanoleuca and Bitis arietans venoms on biochemical, hematological and histopothological indices at different concentrations |
| Country | : | Nigeria |
| Authors | : | Hassan Zanna || Yahaya Tijani || Abubakar Shettima || Miriam Watafua || Rabiu Shehu Sa’ad || Babagana Modu || Najib Bello Abdu |
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: | 10.9790/ 264X-1106026977 |
Abstract: Background: Snakebite is one of the neglected tropical diseases that affects most rural populations with increased mortality. The commercially available antivenoms are expensive and there is less effort to the production of antivenom from indigenous antivenoms that can neutralize various forms of venoms. This study investigated the effects of co-administration of different concentrations of Naja melanoleuca and Bitis arietans venoms on biological parameters.
Materials and Methods.....
Key words: Snakebites, Naja melanoleuca, Bitis arietans, antivenom, alanine aminotransferase, alkaline phosphatase
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