Series-1 (Sep. – Oct. 2025) Sep. – Oct. 2025 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Title |
| Country | : | |
| Authors | : | xxx |
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: | 10.9790/ 264X-1105010108  |
Abstract: The 21 st century witnessed an accelerating convergence of three paradigm shifting technologies: stem cell biology, genomic engineering and artificial intelligence. Although both disciplines are strong individually, the combination of the two disciplines is providing new possibilities in the medical field to an unfathomable degree. This paper will comment on this synergy by looking at how artificial intelligence (AI) is making CRISPR-Cas9 gene editing of stem cells more accurate and more effective. This is the highly potent duo that is transforming science fiction therapies into something that is tangible in their existence.
[1].
[Induced Pluripotent Stem Cells] Takahashi, K., & Yamanaka, S. (2006). Induction Of Pluripotent Stem Cells From Mouse Embryonic And Adult Fibroblast Cultures By Defined Factors. Cell, 126(4), 663–676.
[2].
[Foundational CRISPR-Cas9 Discovery] Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012). A Programmable Dual-RNA-Guided DNA Endonuclease In Adaptive Bacterial Immunity. Science, 337(6096), 816–821.
[3].
[CRISPR-Cas9 In Human Cells] Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., ... & Zhang, F. (2013). Multiplex Genome Engineering Using CRISPR/Cas Systems. Science, 339(6121), 819–823.
[4].
[AI For On-Target Grna Design - Deepcrispr] Chuai, G., Ma, H., Yan, J., Chen, M., Hong, N., Xue, D., ... & Wei, J. (2018). Deepcrispr: A Deep Learning-Based Model For The Prediction Of CRISPR/Cas9 Guide RNA Cleavage Efficiency. BMC Bioinformatics, 19(1), 1-12.
[5].
[AI For On-Target Grna Design - Azimuth] Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimozhang, E. W., Thompson, J. F., ... & Root, D. E. (2016). Optimized Sgrna Design To Maximize Activity And Minimize Off-Target Effects For Genetic Screens With CRISPR-Cas9. Nature Biotechnology, 34(2), 184–191.
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| Paper Type | : | Research Paper |
| Title | : | Biochemical And Haematological Effects Of Ethanol Leaf-Extract Of Cnidoscolus Aconitifolius In Testosterone Propionate-Induced Benign Prostate Hyperplasic Rats |
| Country | : | Nigeria |
| Authors | : | Valentine Osita Godwin Nwobodo || Udu Ama Ibiam || Charles Chiedozie Ndu || Obiajulu Christian Ezeigwe || Obasi Uche Orji || Adachukwu Lilian Chukwu || Blessing Ngozi Osita |
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: | 10.9790/ 264X-1105010920 |
Abstract: The study investigated the biochemical and hematological effects of the ethanol leaf extract of Cnidoscolus aconitifolius in testosterone propionate-induced benign prostate hyperplasia (BPH) rats. Thirty male albino rats were divided into six groups of 5 rats each. Group 1 received subcutaneous administration of 1 ml/kg body weight of olive oil and 1 ml/kg of distilled water orally. Groups 2 to 6 were induced with BPH through daily subcutaneous injection of 3 mg/kg testosterone propionate followed by oral administration of the extract. Group 2 received 1 ml/kg distilled water; Group 3 received.......
Keywords: Cnidoscolus aconitifolius, benign prostate hyperplasia, haematology, dihydrotestosterone, ethanol leaf-extract.
[1]. Ajiboye BO, Oyinloye BE, Agboinghale PE, Ojo OA. Cnidoscolus Aconitifolius (Mill.) I. M. Johnst Leaf Extract Prevents Oxidative Hepatic Injury And Improves Muscle Glucose Uptake Ex Vivo. Journal Of Food Biochemistry, (2019); 43(12): 1-8.
[2]. Atata JA, Ayoola TO, Ajadi AA, Adamu S, Olatunji AO, Biobaku KT. Anti-Anaemic Effect Of Ethanol Leaf Extract Of Cnidosculusaconitifolius On Cyclophosphomide-Induced Anemia In Rats. Journal Of Complementary And Integrative Medicine, (2020); 18(1): 87–92.
[3].
Atroshchenko MM, Shitikova AM, Krokhotina LV, Engalycheva MG, Dmitrieva MN. Effect Of Testosterone, Dihydrotestosterone, Estradiol And Cortisol On The Quality Of Fresh And Cryopreserved Stallion Sperm.Journal Of Experimental Biology And Agricultural Sciences, (2022); 10(3): 619 – 627.
[4]. Bautista-Robles V, Guerrero-Reyes G, Sánchez-Torres GI, Parada-Luna F, Barrios-Gutiérrez JJ, Vázquez-Cerero D, Keita H. Cnidoscolus Aconitifolius: Usosterapéuticos Y Propiedadesfitoquímicas. Revisión De La Literatura. Revista De La Facultad De Medicina, (2020); 68(3): 1-8.
[5]. Bhattacharjee P, Bhattacharyya D. Characterization Of The Aqueous Extract Of The Root Of Aristolochia Indica: Evaluation Of Its Traditional Use As An Antidote For Snake Bites. Journal Of Ethnopharmacology, (2013);145(1):220-226.