Series-1 (Jul. – Aug. 2025) Jul. – Aug. 2025 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Oxidative Stress Suppress Diabetic Patients but Dietary fiber reduces the risk of oxidative stress |
| Country | : | India |
| Authors | : | K. Rajan |
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: | 10.9790/ 264X-1104010105  |
Abstract: Oxidative stress which influences the glucose profile & lipid profile in diabetic patients. Patient with diabetes may also prominent to the symptoms that are repercussion upon the altered glucose & lipid profile levels. The study shows that, comparison of glucose & lipid profiles variations in oxidative stress contain diabetic patients. Blood sugar control which is done by Dietary fiber intake. Materials & Methods- The study was conducted over a period of six months. In this study 30 subjects are diabetic & 20 subjects are control. Diabetic patients are selected. Both males and females were included. Blood sample were collected for estimation of Fbs, PPbs, lipid profile.......
Keywords: Fbs, PPbs, lipid profiles (total cholesterol, HDL, LDL, VLDL, TGL).
[1]
Estimation of glucose by the method of GOD-POD. [Trinder, P. (1969, Annals. Clin. Bio Chem, 6, 24].
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Schettler, G. and Nussel, E., Arb. Med, soz. Med. 10, 25 (1975).
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| Paper Type | : | Research Paper |
| Title | : | Challenges in Fungal and Mushroom Genome Extraction: Technical, Biological, and Methodological Perspectives |
| Country | : | India |
| Authors | : | Umesh Sikarware || Dr. R.K. Tenguria |
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: | 10.9790/ 264X-1104010612 |
Abstract: Fungi, including mushrooms, constitute a taxonomically rich and functionally diverse kingdom with significant ecological, industrial, and pharmaceutical relevance. Genomic studies in fungi have expanded rapidly, yet the extraction of high-quality genomic DNA remains a critical and technically challenging step. These difficulties stem from the rigid and multilayered composition of fungal cell walls, the abundance of inhibitory substances such as polysaccharides and secondary metabolites, and species-specific ecological adaptations. Such factors can compromise DNA yield, purity, and the efficiency of downstream molecular applications including taxonomy, phylogenetics, genome sequencing.......
Keywords: Fungal, Genomics, Mushroom, DNA, Cell, Metabolites, Molecular, Extraction, Mycological Biodiversity, PCR, Inhibitors, Biotechnological ETC.
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Adams, R. I., et al. (2013). The diversity and distribution of fungi on residential surfaces. PLoS One, 8(11), e78866. https://doi.org/10.1371/journal.pone.0078866
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Aghajani, S., & Rafiee, G. (2019). Optimization of fungal DNA extraction protocols for downstream molecular applications. Molecular Biology Reports, 46(3), 2943–2950. https://doi.org/10.1007/s11033-019-04717-4
[3].
Al-Sadi, A. M., et al. (2018). Evaluation of DNA extraction methods for fungi in plant tissues. Molecular Biotechnology, 60(2), 103–113. https://doi.org/10.1007/s12033-017-0057-4
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Becker, B., et al. (2016). Improved DNA extraction protocol for filamentous fungi from soil samples. Journal of Microbiological Methods, 130, 95–102. https://doi.org/10.1016/j.mimet.2016.07.009
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Benson, D. A., et al. (2012). GenBank. Nucleic Acids Research, 40(D1), D48–D53. https://doi.org/10.1093/nar/gkr1209
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| Paper Type | : | Research Paper |
| Title | : | Study the effect of aqueous Extract of Moringa Oleifera plant leaves On Gram-positive bacteria |
| Country | : | Iraq |
| Authors | : | Salih Abdul Mahdi || Batoul Allam Khazim || Baneen ahmed abdul Hamza |
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: | 10.9790/ 264X-1104011317 |
Abstract: Background: A growing therapeutic challenge is being presented by the significant rise in antibiotic resistance in recent years. Using plant-based antibiotic resistance inhibitors is one way to lessen antibiotic resistance. So this study aimed to evaluate the antibacterial properties of aqueous leaf extracts of Moringa Oleifera (M. Oleifera) plant against gram positive pathogenic bacteria staphylococcus aureus (S. aureus) isolated from wounds. Materials and Methods: Using the agar diffusion method, the antibacterial activity of Moringa oleifera leaf extracts was assessed in vitro............
Key Word: Maringa Oleifera; leaves extract; S. aureus; diffusion method.
[1].
Guido François, Tania Steenackers, Laurent Aké Assi, Wolfgang Steglich, Kai Lamottke, Jörg Holenz, Gerhard Bringmann (1999), "Vismione H and structurally related anthranoid compounds of natural and synthetic origin as promising drugs against the human malaria parasite Plasmodium falciparum: structure-activity relationships", Parasitology Research, vol. 85, no. 7, pp. 582–588
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Ahn K (2017). "The worldwide trend of using botanical drugs and strategies for developing global drugs". BMB Reports. 50 (3): 111–116.
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| Paper Type | : | Research Paper |
| Title | : | Rewriting the Surgical Margin Landscape: Tumor Microenvironment and Its Implications for Margins and Recurrence in Solid Tumors |
| Country | : | India |
| Authors | : | Avinash Sharma || Syeda Samrin Ghani |
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: | 10.9790/ 264X-1104011826 |
Abstract: Background: Surgical resection remains the primary curative modality for solid tumors, with negative surgical margins traditionally viewed as a benchmark for success. However, recurrence occurs even after histologically clear margins, indicating the involvement of non-anatomical factors — particularly the tumor microenvironment (TME). Objective: T............
Key Word: Tumor microenvironment, Surgical margins, Solid tumors, Recurrence, Immuno-oncology, Cancer-associated fibroblasts, Spatial transcriptomics, Fluorescence-guided surgery.
[1].
Mahvi DA, Liu R, Grinstaff MW, Colson YL, Raut CP. Local cancer recurrence: the realities, challenges, and opportunities for new therapies. CA Cancer J Clin. 2018;68(6):488–505.
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Sosa A. CSF1R inhibitors in perioperative settings. Cancer Lett. 2023;561:168112.
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Markman JL, Shiao SL. Impact of the immune system and tumor microenvironment on surgical outcomes in cancer. Cancer Biol Ther. 2015;16(8):670–9.
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Arneth B. Tumor Microenvironment. Medicina (Kaunas). 2019;56(1).
[5].
Giraldo NA, Sanchez-Salas R, Peske JD, Vano Y, Becht E, Petitprez F, et al. The clinical role of the TME in solid cancer. Br J Cancer. 2019;120(1):45–53.
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| Paper Type | : | Research Paper |
| Title | : | CRISPRi-Guided Evaluation of Functionalized Silver Nanoparticles for Targeted Inhibition of HIV-1 via gp120–CD4 Interface Disruption |
| Country | : | India |
| Authors | : | Anjaleena T.G || Sumit kumar |
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: | 10.9790/ 264X-1104012739 |
Abstract: This study explores the antiviral effects of silver nanoparticles (AgNPs) designed to target the HIV-1 envelope glycoprotein gp120 to impede HIV entry into host cells and subsequently inhibit replication. AgNPs were manufactured through chemical and green methods and a detailed characterization of all AgNPs (in all its forms) was conducted by transmission electron microscopy (TEM), ultraviolet-visible (UV-vis) spectroscopy, dynamic light scattering (DLS) and zeta potential analysis to verify size, morphology, and surface stabilization through characterization approaches. The anti-gp120 monoclonal antibody further lent to the specificity and enablement of viral binding of their signature gp120 proteins. Two lentivirus infected human cell lines (MT-4 and TZM............
Key Word: Silver Nanoparticles, HIV-1 Inhibition, gp120 Targeting, Antiviral Therapy, CRISPRi Profiling, Viral Entry Blockade, Microbial Nanomedicine
[1].
Mukherjee, S., Bytesnikova, Z., Martin, S., Svec, P., Ridoskova, A., Pekarkova, J., ... & Adam, V. (2023). Silver Nanoparticle‐Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV‐1 Infection. Advanced Materials Interfaces, 10(6), 2201996.
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Asl, F. D., Mousazadeh, M., Taji, S., Bahmani, A., Khashayar, P., Azimzadeh, M., & Mostafavi, E. (2023). Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles. Nanomedicine, 18(3), 279-302.
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Ratan, Z. A., Mashrur, F. R., Chhoan, A. P., Shahriar, S. M., Haidere, M. F., Runa, N. J., ... & Cho, J. Y. (2021). Silver nanoparticles as potential antiviral agents. Pharmaceutics, 13(12), 2034.
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Tiwari, A. K., Gupta, M. K., Pandey, G., Pandey, S., & Pandey, P. C. (2023). Amine-functionalized silver nanoparticles: A potential antiviral-coating material with trap and kill efficiency to combat viral dissemination (COVID-19). Biomedical Materials & Devices, 1(2), 618-632.
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Mortazavi-derazkola, S., Ghoreishi, S. M., Mohammadzadeh, P., & Roueinfar, M. (2024). Targeting strategies and clinical implications of bio-conjugated silver nanoparticles in drug delivery. In Silver Nanoparticles for Drug Delivery (pp. 67-87). Academic Press.