Version-1 (May–June 2016)
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| Paper Type | : | Research Paper |
| Title | : | Association between VDR Gene Polymorphism and HBV Related HCC |
| Country | : | Egypt |
| Authors | : | Khalifa AS || Khodeer S || Eed EM || Alwakeel HR |
Abstract: Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers. The majority of these cases are related to chronic viral hepatitis. Several VDR gene single nucleotide restriction(SNP) have been described in association with neoplastic and non-neoplastic diseases. The aim of this study was to explore the association between VDR polymorphism and development of HCC and liver cirrhosis in chronically HBV infected patients....
Key words: VDR polymorphism, HCC, HBV
[1]. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69–90.
[2]. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132: 2557–2576.
[3]. Kuper H, Tzonou A, Kaklamani E, Hsieh CC, Lagiou P, et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 2000; 85: 498–502.
[4]. Wang PR, Xu M, Toffanin S, Li YL, Lovet JM, Russell DW. Induction of hepatocellular carcinoma by in vivo gene targeting. Proceedings of the National Academy of Sciences of the United States of America, 2012; 109 (28):11264–11269.
[5]. Ma NF, Lau SH, Hu L, Dong SS, Guan XY. Hepatitis B virus X gene in the development of hepatocellular carcinoma. Hong Kong Medical Journal 2011; 17( 6): 44–47.
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| Paper Type | : | Research Paper |
| Title | : | Acceptance of novel foods for physical activity practitioners formulated with Spirulina |
| Country | : | Brazil |
| Authors | : | Lisiane Fernandes de Carvalho || Juliana Botelho Moreira || Mariana Souza de Oliveira || Jorge Alberto Vieira Costa |
Abstract: The diet of athletes require higher caloric intake, which should be provided by special food intake. The biomasses of microalgae are innovative alternative natural ingredients that can be used in the development of foods. Spirulina is a source of protein and amino acids, antioxidants, carbohydrates, vitamins and minerals. The objective of this study was to evaluate the acceptance and purchase intention to foods developed with Spirulina intended for athletes.............
Key words:Athletes, microalgal biomass, purchase intention, supplement food.
[1] L.M. Burke, J.A. Hawley, S.H.S Wong, and A.E. Jeukendrup, Carbohydrates for Training and Competition. Journal of Sports Sciences, 29 (S1), 2011, S17-S27.
[2] Dietitians of Canada (DC), American College Sports Medicine (ACSM) & American Dietetic Association (ADA), Nutrition and athletic performance: a joint position statement. Medicine and Science in Sports and Exercise, 41, 2009, 709-731.
[3] G. Slater, and S. Phillips, Nutrition guidelines for strength sports: Sprinting,weightlifting, throwing events, and bodybuilding. Journal of Sports Sciences, 29(S1), 2011, S67-S77.
[4] J. Driskell, Vitamins and trace elements in sports nutrition, in J. Driskell, and I. Wolinsky (Ed). Sports Nutrition. Vitamins and Trace Elements, (CRC/Taylor & Francis, New York, 2006) 323-331.
[5] B.S. Vaz, J.B. Moreira, M.G. Morais, and J.A.V. Costa, Microalgae as a new source of bioactive compounds in food supplements. Current Opinion in Food Science, 7, 2016, 73-77.
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| Paper Type | : | Research Paper |
| Title | : | Estimation of Copper, Malondialdehyde and Ceruloplasmin Levels in Senile and Diabetic Cataract |
| Country | : | Brazil |
| Authors | : | Dr. Asiya Naaz || M.Shukhavani || Dr.P.Suhasini || Dr. Mohammed Meraj Ahmed |
Abstract: Cataract is one of the major causes of impaired vision and blindness worldwide and is most simply defined as opacity of the crystalline lens. Any alteration in the optical homogeneity of the lens or decrease in its transparency is known as a cataract [1]. Senile cataract, a major cause of blindness worldwide, is an-age associated condition[2,3]. The term senile refers to the fact that no specific ophthalmic or metabolic diseases are known to precede or to be involved in this type of cataract [4]. Based on the etiology cataract can be divided into senile or age-related cataract, congenital cataract and cataract associated with systemic disease [
[1]. Hejtmancik J.F. and Kantorow M. (2004) Exp. Eye Res., 79, 3-9.
[2]. Hoenders, J.H. and Bloemendal, H. (1981) In Molecular and cellular biology of the eye lens
[3]. (Bloemendal H, ed.) pp.279-326. New York: John Wiley.
[4]. Leske, M.C. and Sperduto, R.D. (1983) The epidemiology of senile cataracts: a review. Am. J. Epidemiol. 118, 152-65.
[5]. Boutros, G., Koch, H.R., Jausen, R., Jacob, T.J. and Duncan, G. (1984) Effects of 8- methyoxypsorales on rat lens cations membrane potential and protein levels. Eye Eye Res. 38, 509-13.
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| Paper Type | : | Research Paper |
| Title | : | Serum Lipid Profile and Fasting Insulin Levels in Second Trimester of Pregnancy As Predictors of Pregnancy Induced Hypertension |
| Country | : | India |
| Authors | : | Dr.suhasini padugupati || Dr.Asiya naaz || Mr.Dudekula Moulali || Dr. D.V.H.S Sarma |
Abstract: Pregnancy is a physiological process in women but it may be associated with certain risks to the health and life of both the mother and child. Hypertensive disorders complicating pregnancy are common and form one of the deadly triad along with hemorrhage and infection that results in maternal and perinatal morbidity and mortality in both under developed and developed countries[1].Hypertension after 20 weeks pregnancy in a woman with edema and proteinuria without previous history of hypertension is called pregnancy induced hypertension. When associated with proteinuria, the disorder is termed preeclamptic- eclampsia/toxemia, and when present without protein in urine it is called transient hypertension
[1]. Dutta D.C. Hypertensive disorders in pregnancy. In: Konar H.L., editor. Textbook of Obstetrics, 5th edition. Kolkata: New Central Book Agency; 2001. pp. 234–55.
[2]. Poston RN, Haskard DO, Coucher JR , Gall NP, Johnsox – Tidey RR, et al. Expression of intercellular adhesion molecule-1 in atherosclerotic Plaques. Am J pathol.1992; 140: 665-673.
[3]. Davies MJ , Gordon JL , Gearing AJH , Pigolt R, Woolf N , Katz D , Kyriakopoulos A, et al . The expression of the adhesion molecules ICAM,VCAM-1, PECAM, and E- selection in human atherosclerosis.J.pathol.1993; 171: 223- 229.
[4]. O' Brien KD, Allen MD, McDonald To, Chait A, Harlan J M, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin CD, et al Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of progression of advanced coronary atherosclerosis. J clin Invest, 1993; 92: 945-957.
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| Paper Type | : | Research Paper |
| Title | : | Anti-Hyperglycaemic Activity and Antioxidant Properties of Pepper Waste and Fruit |
| Country | : | Turkey. |
| Authors | : | Fatma Kubra Sayin |
Abstract: The objective of this study was to determine content of major antioxidants, antioxidant activity, and anti-hyperglycaemic activity in different fractions (seeds, peel, and fruit) of 7 pepper cultivars. Peppers were examined for their total phenolic (TP), total flavonoid (TF), total carotenoid (TC) contents, and antioxidant activity using a DPPH assay. The inhibitory activity of pepper fractions against yeast α-glucosidase and porcine pancreatic α-amylase were used to determine anti-hyperglycaemic activity........
Keywords: antioxidant capacity, Anti-hyperglycaemic activity, pepper, total carotenoids, total flavonoids, total phenol
[1]. X. Wang, Y. Ouyang, J. Liu, M. Zhu, G. Zhao, W. Bao, and F.B. Hu, Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies, British Medical Journal 349, 2014, 4490–4498.
[2]. H. Nishino, M. Murakosh, H. Tokuda, and Y. Satomy, Cancer prevention by carotenoids, Archives of Biochemistry and Biophysics, 483, 2009, 165–168.
[3]. K.A. Youdin and J.A. Joseph, A possible emerging role of phytochemicals in improving age related neurological dysfunctions: a multiplicity of effects. Free Radical Biology and Medicine, 30, 2001, 583–594.
[4]. J.J. Lee, K.M. Crosby, L.M. Pike, K.S. Yoo, and D.L. Lescobar, Impact of genetic and environmental variation of development of flavonoids and carotenoids in pepper (Capsicum spp), Scientia Horticulturae, 106, 2005, 341–352.
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| Paper Type | : | Research Paper |
| Title | : | Histopathology of the Pancreatic Cells of Alloxan Induced Wistar Rats Treated With Psidium Guajava Ethanolic Leaf Extract |
| Country | : | Nigeria |
| Authors | : | Nosiri C.I || Atasie O.C || Alvan V.C. || Ifedigbo O |
Abstract: The histopathological effect of the pancreatic cells of alloxan induced diabetic rats treated with ethanolic leaf extract (200 and 400mg/kg p.o) of psidium guajava was investigated. The experiment lasted for 10 days. A standard drug Glinbeclamide (5mg/kg p.o) was also used to compare the potency of the different doses of the extract. The alloxan (150mg/kg) treated showed loss in body weight, hyperglycemia and damage of the islet cells of the pancreas...........
Keywords: Alloxan, diabetes, Histopathology, pancreatic cells, psidium guajava,
[1]. B. Joseph and M. Priya, Review on nutritional, medicinal and pharmacological Properties of guava (psidium guajava. linn.) International Journal of Pharma and Bio Sciences, 2 (1) 2011, 53
[2]. N. M.A. Hassimotto, M.I. Genovese, F.M. Lajolo, Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. Journal of Agri-culture and Food Chemistry 53, 2005, 2928-2935
[3]. A. Jimenez-Escrig, M. Rincon, R. Pulido, and F. Saura-Calixto, Guava fruit (Psidium guajava L.) as a new source of antioxidant dietary fiber. J. Agri. Food Chem., 49, 2001, 5489–5493
[4]. W. Fang , C. Yong-Hong ,Yu-JieZhang, D. Gui-Fang , Z. Zhi-Fei ,An-NaLi, Dong-PingXu, Hua-Bin Li, Chemical Components and Bioactivities of Psidium guajava, International Journal of Food Nutrition and Safety, 5(2), 2014, 98-114
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| Paper Type | : | Research Paper |
| Title | : | Hypolipidemic, Hypoglycemic and Antiproliferate Properties of Chia Seed Oil and its blends with Selected Vegetable Oils-An in-vitro study |
| Country | : | India |
| Authors | : | Ramzi AbdulrashedAbdulkhaleq Gazem || Honnalagere Ramesh Puneeth || Angatahally Chandrashekaraiah Sharada |
Abstract: Numerous studies conclude that inflammatory pathways predommint the pathophysiology of major metabolic syndromes like of diabetes and cardiovascular diseases (CVD). In particular, pancreatic lipase is increased during diabetes and CVD pathology. There is a gradual hepatotoxicity associated with the modern allopathic drugs though efficiently maintain the blood glucose levels but on a long run injure the vital tissues like kidney and liver............
Keywords: hypolipidemic, Gluconeogenesis, diaphragm, Anti-proliferation.
[1]. R. Ayerza, Oil content and fatty acid composition of chia (Salvia hispanica L.) from five northeastern locations in northwestern Argentina, Journal of the American Oil Chemists' Society, 72,1995, 1079-1081.
[2]. R.A.A. Gazem, A.C. Sharada, Pharmacological properties of salvia hispanica (Chia) seeds: A review, Journal of critical review, 3(3),2016, 2394-2399.
[3]. V.Y. Ixtaina, M.L. Martinez, V. Spotorno, C.M. Mateo, D.M. Maestri, B.W.K. Diehl, S.M. Nolasco, M.C. Tomas, Characterization of chia seed oils obtained by pressing and solvent extraction, Journal of Food Composition and Analysis, 24(2), 2011, 166-174.
[4]. E. Reyes-Caudillo, A. Tecante, M A. Valdivia-Lopez, Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds, Food Chemistry, 107, 2008, 656-663.
[5]. A.A. Izadpanah, Short-term Diet and Exercise Intervention Ameliorates Inflammation and Markers of Metabolic Health in Overweight/Obese Children, The Journal of Endocrinology and Metabolism, [epub ahead of print], 2012, 1-19.
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| Paper Type | : | Research Paper |
| Title | : | Paclitaxel - Development, Properties, Toxicity/Safety Evaluation and the Scope of Improvement |
| Country | : | India |
| Authors | : | Mohammad Aamir Bhat || Chandresh Varshneya || Pallavi Bhardwaj || Rajendra Damu Patil |
Abstract:Paclitaxel is a miraculous drug that is being extensively used against ovarian and breast carcinomas. Since its approval as a chemotherapeutic agent against breast and ovarian carcinomas, in April 1994, paclitaxel has been studied extensively leading to the tremendous development of its efficacy and alleviating its toxicity potential. It has been encapsulated in nanoparticles and emulsified with different types of solvents to observe its pharmacokinetics, toxicity, anticancer effects and resistance at a whole different level............
Keywords: Carcinoma, cremophor EL, encapsulation, toxicity, paclitaxel.
[1]. Sonia M, Rosa MC, Mohammad HM, Elisabeth M, Javier P and Mercedes B. 2011. Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review. Process Biochemistry 46 (2011): 23-34.
[2]. Rowinsky EK, Onetto N, Canetta RM and Arbuck SG. 1992. Taxol: the first of the taxanes, an important class of antitumor agents. Seminars in Oncology 19 (6): 646-662.
[3]. Rowinsky EK and Donehower RC. 1995. Paclitaxel (taxol). New England Journal of Medicine 332 (15): 1004-1014.
[4]. Singla AK, Garg A and Aggarwal D. Paclitaxel and its formulations. 2002. International Journal of Pharmaceutics 235 (2): 179-192.
[5]. Lee J, Lee SC, Acharya G, Chang CJ and Park K. 2003. Hydrotropic solubilization of paclitaxel: Analysis of chemical structures for hydrotropic property. Pharmaceutical Research 20 (7): 1022-1030.
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| Paper Type | : | Research Paper |
| Title | : | The interplay of antioxidant activities in rats exposed to sub chronic low level inorganic mercury is gender specific |
| Country | : | Nigeria |
| Authors | : | Wusu A. D. || Ogunrinola O. O. || Ojekale, A.B || Olaitan S. || Onwordi, C.T || Auta, R |
Abstract: To investigate sex differences in the effects of inorganic mercury on antioxidant enzymes in different compartments, male and female albino rats were exposed to mercury (0.5, 1.0 and 1.5mg/kg) for 12 weeks. Post exposure, total mercury in liver, kidney and whole blood was determined using Inductively-Coupled Plasma Spectrometry (ICP-MS) while superoxide dismutase (SOD) and catalase (CAT) activities in the liver, kidney, plasma and erythrocytes were also determined. Inhibition of CAT and SOD in plasma and erythrocyte characterised the effects of inorganic mercury in female animals with the same trend in SOD of the male............
Keywords: Inorganic mercury, Antioxidant enzymes, superoxide dismutase (SOD), Catalase (CAT).
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[4]. Borras, C., Sastre, J., Garcia-Sala, D., Lloret, A., Pallardo, F.V. and Vina, J. 2003. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free radical biology & medicine 34, 546-552.
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