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Research Paper |
| Title |
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Synthesis And Biological Evaluation Of Novel 5-Methyl-1, 4-
Disubstituted 1h-1, 2, 3-Triazole Derivatives |
| Country |
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India |
| Authors |
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A. Pavani, T.Lakhshmi Viveka |
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10.9790/5736-0333641  |
Abstract: Six triazole derivatives have been synthesized using p- toludine and p- anisidine as starting
materials. Diazotization in presence of NaN3 and followed by cyclisation esterification with absolute methanol
and followed by reduction with NaBH4 and oxidation with NaOCl and NaBr in presence of 2, 2, 6, 6-
tetramethyl-1-piperinyloxy free radical (TEMPO) gave 5-methyl-1-(4-methyl phenyl)-1H-1, 2, 3-triazole-4-
carbaldehyde and 5-methyl-1-(4-methoxy phenyl)-1H-1, 2, 3-triazole-4-carbaldehyde (5a & 5b). Finally,
compounds 5a and 5b on condensation with primary amines like cyclohexyl amine, (+) phenyl ethyl amine, (-)
phenyl ethyl amine using sodium triacetoxy borohydride gave 5-methyl- 1, 4- disubstituted-1H-1, 2, 3-triazole
derivatives (6a – f).
Keywords :Triazole, sodium triacetoxy borohydride, carbaldehydes, amines, antibacterial, anti-inflammatory.
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