Volume-9 ~ Issue-5 ~ May-2016

Abstract: Drug molecule experiences variety of interactions with bio membranes once it is administered in the body. Bio membranes too experiences changes in the strategic parameters like permeability, charge transfer and fluidity on interactions with the drug molecule. Pharmacokinetics as well as Pharmacodynamics gets affected. Understanding of these interactions is very important as it may lead into the development of new antineoplastic drugs or can improve upon the efficacy profile of existing Drug molecule...........
Keywords: Drug, Bio membrane, in vitro, in silico, transport.

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[3]. Brezesinski G, Mohwald H., " Langmuir monolayers to study interactions at model membrane surfaces",Adv Colloid Interface Sci.2003,100(102) pp 563-84

[4]. Hubert Bader , Klaus Dorn, Bernd Hupfer, Helmut Ringsdorf, "Polymeric monolayers and liposomes as models for biomembranes",Polymer Membranes.2005,64 pp 1-62

[5]. M.J.Hope,M.B.Bally, G.Webb and P.R.Cullis,"Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution,trapped volume and ability to maintain a membrane potential" Biotechniques 1989,7(5) pp 466-75.

Abstract: The degree inversion ferrite of Cu(1-x)ZnxFe2O4 has been studied by using of the Rieltvelt refinement of XRD data method. Generally give a good result, then it may be used as a reference of the comparative study. The Flow Injection Synthesis-FIS is one of method forming of iron oxide such as ferrite material use principle thermodynamic then either the activation energy, entropy or Seebeck constant of material may be obtained well. The Cu(1-x)ZnxFe2O4 is one of may obtain entropy cause un-stable substance was marked by trend exchange of entropy............
Keywords:co-precipitation, ferrite, non-isothermal process, crystallization, , data logger acquisition system, flow injection synthesis-FIS, inversion degree .

[1]. Skomski R and Coey J M D 1999 Permanent Magnetism (Bristol: Institute of Physics Publishing). [2]. Kaiser Robert And . Rosensweig. Ronald , avco corporation lowell, mass. For Nat.aeronautics and space administration washington, D.C.,Study of ferromagnetic liquid, Nasa contractor Report ., washington dc. [3]. Charles S W 1992 Studies of Magnetic Properties of Fine Particles and their Relevance to Materials Scienceed J L Dormann and D Fiorani (Amsterdam: Elsevier) p 267 [4]. [Mohapatra, S.; Mallick, S. K.; Maiti, T. K.; Ghosh, S. K.; Pramanik, P., "Synthesis of highly stable folic acid [5]. conjugated magnetite nanoparticles for targeting cancer cells." Nanotechnology 2007, 18, (38)..

Abstract: Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Rosuvastatin Calcium, Alfuzosine hydrochloride, Atorvastatin Calcium, Ibandronate sodium, Imatinib Mesylate based on their reactivity towards Chloramine-T. The method of each drug depends upon oxidation of drugs by Chloramine-T (Excess) and estimating the amount of unreacted Chloramine-T by Rhodamine-B dye at λmax 557nm. These methods have been applied for the determination of drugs in their pure form as well as in tablet formulations. The effect of excipients has also been studied and found to have no effect. These methods have been validated in terms of guidelines of ICH.............
Keywords: Spectrophotometry, Drugs, Chloramine-T, Rhodamine-B, Quantification, Validation

[1]. Kaila HO, Ambasana MA, Thakkar RS, Saravaia HT, Shan AK. A New improved RP-HPLC Method for assay of rosuvastatin calcium in tablets. Indian J of Pharmaceutical Sciences 2010; 72: 592-598.

[2]. S.C. Sweetman Martindale-The Complete Drug Reference (thirty-sixth ed.), 1The Pharmaceutical Press, London, UK (2009) pp. 1218–1219, 1238–1239, 1284–12851310, 1307–1310.

[3]. Trivedi R.K. Kallem R.R. Mullangi R. Srinivas N.R., Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC–MS/MS with electrospray ionization: Assay development, validation and application to a clinical study, J Pharma Biomed Anal., 2005, 39, 661-669.

[4]. Xu D.H. Ruan Z.R. Zhou Q. Yuan H. Jiang B., Quantitative determination of rosuvastatin in human plasma by liquid chromatography with electrospray ionization tandem mass spectrometry, Rapid Commun Mass Spectrum., 2006, 20, 2369-2375.

[5]. Kallem R.R. Karthik A. Chakradhar L. Mullangi R. Srinivas N.R., Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for quantification of rosuvastatin in small volume human plasma samples and its application to a clinical study, Arzneimittel forsch., 2007, 57, 705-11

Abstract: β-acetamido ketones were synthesized in high yields under mild condition via four component Dakin-West reaction which carried out by condensation of aromatic aldehydes, enolizable ketones, acetonitrile and acetyl chloride in presence of mixed metal oxide CuO-SnO2 as versatile catalyst. The biological study of compounds codeine was used as supplementary drug in combination of the resultant Dakin-West compounds. Interesting results were obtained in accordance with the principle of 'Synergism'. It was observed that, synthesized β-acetamidoketones and supplementary drug, Codeine worked together to produced results which were not independently obtainable.
Keywords: Combine drug action, Dakin-West reaction, Synergism, Supplementary drug, Codeine

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Abstract: A new cadmium(II) complex of 2-Aminobenzonitrile(ABN) and Octanoate(OC) ion was synthesized by using microwave irradiation. Microwave synthesis gives high yield of the complex within a short time. The molecular formula and the probable geometry of the complex have been deduced from elemental analysis, infrared, electronic spectra, magnetic susceptibility and electrical conductivity measurements. The molar conductance value indicates that the Cd(II) complex is a non-electrolyte. The FT-IR spectra show that 2-aminobenzonitrile is coordinated to the metal ion in a bidentate and octanoate ion in a monodentate manner. The nature of the bonding in this diamagnetic complex was arrived from the NMR spectra..............
Keywords: Cadmium(II) complex, 2-Aminobenzonitrile, Octanoate ion, Antimicrobial

[1] Kasuga NC, Sugie A, Nomia K. 2004 Dalton Trans. 21 3732-3740.
[2] Lin P, Handersen RA, Harrington, Clegg W, Wu C-D, Wu X-T 2004 Inorg. Chem. 43 181-188.
[3] Seward C, Jia W-L, Wang R-Y, Enright GD, Wang S 2004 Angew. Chem. Int Edn.43 2933-2936.
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Abstract: The monomer 3, 6- DI-isocyanato N – hexyl carbzole has been synthesized and two substituted poly ureashave been synthesized by the reaction of monomer 3,6- Di –isocyanato N –hexyl Carbazole with 1, 4- Diamino benzene and benzidine.The monomer and the corresponding two poly ureas have been Characterized by UV,IR and NMR spectroscopy.
Keywords: 3, 6- Di-isocyanato N-hexyl carbazole, substituted poly ureas, Interfacial polymerization.

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Abstract:Porous ceramic filters were prepared by incorporating burnout material into the clay and their efficiency in removal of turbidity and Escherichia coli tested. Moringa oleifera seeds were also tested for their biocoagulant and phytodisinfectant ability in purifying water. The filters reduced E. coli from 390±10 CFU/ml to 0.00 - 0.03 CFU/ml corresponding to an efficiency range of 99.1 to 100%. Turbidity reduced from 64.13±0.75 NTU to 0.92-1.77 NTU equivalent to 97.2............
Keywords: Ceramic filters, M. oleifera, drinking water, E. coli, turbidity

[1] UN-Water Global Analysis and Assessment of Sanitation and drinking-water (GLAAS) 2014 – report. Investing in water and sanitation: increasing access, reducing inequalities.
[2] World Health Organization and UNICEF 2013- Progress on sanitation and drinking-water update.
[3] United Nation World Water Development Report (UNWWDR) 2014. Water and Energy volume one.
[4] Walker C.L., Rudan I., Liu L., Nair,H., Theodoratou, E., Bhutta Z.A., O'Brien K.L., Campbell H., and Black R.E., Global burden of childhood pneumonia and diarrhoea. Lancet 381, 2013, 1405-1416.
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Abstract: Two cross-linkers with different functional groups amide (N,N- Methylenebisacrylamide (NMBA)) and esters (Ethylene Glycol Dimethylacrylate (EGDMA)) have been selected for comparative study for cross-linking polyaspartic acid (PAsp) and acrylic acid (AA). Thus, resulting in formation of different polymers with PAsp and acrylic acid in different ratios and cross-linked with different cross-linkers. Polymers with maximum PAsp have shown best superabsorbent properties..............
Keywords: Polyaspartic acid (PAsp)(polyamides); Crosslinking; Gels; Swelling; Superabsorbent polymers (SAP)

[1]. Mehr, M.J.Z and Kabiri, K. Iranian Polymer Journal 2008, 17(6), 451-477.
[2]. Chaudhri, S; Datta, Mutha.P ; Prachi, P. Plastics and Packaging 2013, 58(6),19-24.
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Abstract: This research, involved synthesis of a series of new compound containing different derivatives. The synthesis involved treatment of 6- methyl 2-thiouracil with chloroacetyl chloride to give 1- chloroacetyl 6- methyl 2-thiouracil (1) .The product was treat with hydrazine hydrate to give 2- ( aceto hydrazide ) thiouracil (2), and with phenyl hydrazine to give phenyl hydrazide thiouracil (13)...............

Keywords - 6- methyl 2- thiouracil, Schiff bases, 1- chloroacetyl thioracl, phenyl hydrazide derivative.

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Abstract: Ability of intermediate and long chain n-alkane solvents to precipitate asphaltenes (heavy organics) from crude oil residue was investigated. Precipitation by single n-alkane solvents: normal pentane, octane,dodecane and hexadecane(nC5, nC8, nC12, and nC16respectively)was studied vis-à-vis that by their combinations (binary solvent mixtures). The solvent combinations studied were nC8/nC12, nC8/nC16 and nC12/nC16. The results obtained showed that under the same conditions, nC8, nC12, and nC16 solvents precipitated 3.24, 1.28, and 15.27 wt % of Organic solids respectively from crude oil................

Keywords - Asphaltenes, Binary mixtures, Hexadecane, Heavy organics, Dodecane, Octane.

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Abstract: TEach of 5,10,20,30 and 50% aqueous solution of Gum Arabic(GA) was exposed in turn to microwave irradiation power at 100,200 and 300W for 1, 2 and 3 minutes respectively. Dried to constant weight film of each was obtained by casting method and then subjected to characterization by determination of pH, specific gravity(SG), tensile strength(TS), Young's modulus(YM), elongation at beak(EB) and energy at break(EAB). The results showed that increasing microwave irradiation power for longer time was accompanied by increase in processing temperature as concentration of the biopolymer increased..........

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Abstract: The genomic DNA of all living species consists of four DNA bases. These are adenine (A), thymine (T), guanine (G) and cytosine (C). The entire genetic information is consisted in specific order of these bases which varies among living bodies. The integrity of genome and its transfer from parents to offspring depends upon the ability of DNA replication machinery. A mis-matched selection of base by replication machinery can lead to mutation in the genome and thereby may result in unwanted health complications. Various modified DNA bases have.....

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