Abstract: Alkylation of DNA is commonly used during cancer chemotherapy. The most common chemotherapeutic agents are those that alkylate the O6-position of guanine. Attempts were made in the modification of the O6-position of guanine for recognition by methylguaninemethyltranferase (MGMT) enzyme for DNA cross linking studies in an attempt to search for new cancer chemotherapeutic agents. Glycosylation of the pyrrlopyrimidine (modified guanine) was carried out successfully with 1-Chloro-2'-deoxy-3,5-di-O-p-toluoyl--D-erythro-pentofuranose to give the desired nucleoside. Several attempts were made inorder to cyclise the different modified nucleosides...........
Keywords: Alkylation, cancer, chemotherapy, nucleoside, glycosylation
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