iosr-JDMS   Volume-1 ~ Issue-1

Abstract: In developing countries cancer cervix is the leading cause of cancer death in females. Effective screening contributes to decrease mortality. Lack of resources is main factor for failure of effective screening for cervical cancer. VIA, visual inspection of cervix with acetic acid application is low cost approach for cervical cancer screening in low income countries.
Key-words: Cancer, Cervix, Pap smear, Screening, VIA

[1] Feriay J. et.al.,Cancer incidence, mortality, prevalence worldwide (IARC cancer base ,Lyon,2004)
[2] WHO Summary report on HPV& cervical cancer statistics in India (18/03/2008)
[3] Parkin DM, et al Eur. J. Cancer 2001, 37 (Suppl. 8) 54-56
[4] Comprehensive Cervical Cancer Control, A guide to essential practice, WHO (Practice sheet 10 : Visual screening methods 123-124)
[5] Lewis M. Situational analysis of cervical cancer in Latin America and the Caribbean. Washington, DC: Pan American Health Organization;2004
[6] Cervix cancer screening .IARC handbooks of cancer prevention, vol.10. Lyon, France:IARC Press;2004
[7] ACCP: visual screening approaches (Cervical cancer prevention fact sheet (Oct 2000)
[8] Denny L., Kuhn L., Pollack A., Wainwright H, Wright T.C., Jr.(2000)Evaluation of alternative methods of cervical cancer screening for resource poor settings.Cancer,89,826-833
[9] Ottaviano M, La Torre P. Examination of the cervix with the naked eye using acetic acid test. Am J Obstet Gynecol 1982; 143:139-142.
[10] Goldie S.J., Kuhn L., Denny L., Pollack A., Wright T.C. (2001) Policy analysis of cervical cancer screening strategies in low resource settings: clinical benefits and cost effectiveness. JAMA,285,3107-3115

Abstract: An unusual origin of sub scapulo suprascapular arterial trunk was observed in one of the nearly old male embalmed cadaver during routine dissection classes for MBBS students. The sub scapulo supra scapular arterial trunk was seen to emerge from the 1st part of axillary artery on the right side of cadaver. While on left side axillary arterial branches were normal origin. The anomalous sub scapulo supra scapular arterial trunk was courses obliquely between musculocutaneus nerve and median nerve. Total length measured 4.2cms, and terminate into three branches, ventral & dorsal branches to subscapularis muscle and supra scapular branch. The supra scapular branch accompanied by supra scapular nerve, together passed beneath the superior transverse ligament. It then supplied the supra spinatus muscle. And finally took part in the anastomosis around the scapula. The anatomical knowledge of the sub scapular & supra scapular artery is of crucial importance for neurosurgeons and arthropedicians. The improved knowledge would allow more accurate diagnostic interpretations and surgical treatment.
Key words: Axillary artery, Sub scapulo-supra scapular arterial trunk, Superior transverse ligament

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Abstract: Periodontitis is caused mostly by Porphyromonas gingivalis (P. gingivalis) and it relates to acute coronary syndrome. P. gingivalis readily invades into blood circulation and potentially induces collagenolytic activity of neutrophil which results in collagen vascular degradation and leads to atherosclerotic plague rupture (APR). Neutrophil has a role event in APR and is responsible for the occurrence of fatal cardiovascular events such as acute myocardial infarction (AMI). This information brought out notion concerning the adhesion interaction of P.gingivalis with neutrophil. The aim of the study is to assess adhesion molecule of P. gingivalis outer membrane protein (OMP). The study was done by partial characterization taken in hemagglutination assay using mice erythrocytes, adhesion inhibition assay by gradual concentration of adhesion blocked in neutrophil, immunologic assay using Western-blotting and immunocytochemistry. The results showed that 49.4 kDa P. gingivalis OMP can agglutinate mice erythrocytes and adhere to netrophil. The increasing concentration of OMP P. gingivalis 49.4 kDa reduces adhesion process to netrophil. This protein was recognized by the polyclonal antibody of 49.4 kDa adhesion molecule. It can be concluded that 49.4 kDa P. gingivalis outer OMP is a hemagglutinin and an adhesion molecule to netrophil.
Keywords: 49.4 kDa P. gingivalis OMP, neutrophil, hemagglutination, adhesin.

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